LEARNING IN MONKEYS EXPOSED PERINATALLY TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)
LEARNING IN MONKEYS EXPOSED PERINATALLY TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)
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DOI：
10.1016/0892-0362(89)90080-9
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发表时间：
1989-01-01
影响因子：
2.9
通讯作者：
BOWMAN, RE
中科院分区：
文献类型：
--
作者：
SCHANTZ, SL;BOWMAN, RE
TCDD是一种毒性极强的化学污染物，可在母体脂肪组织中积累，并在妊娠期和哺乳期转移到发育中的生物体。据报道，围产期暴露于多氯联苯后会出现长期认知缺陷，多氯联苯在结构和毒理学上与四氯二苯并对二恶英相似。在目前的研究中，猴子暴露于TCDD围产期后来在两个认知范式，歧视逆转学习（RL）和延迟空间交替（DSA）进行了测试。RL检测到效应;而DSA，分析，没有。强化学习包括一系列简单的空间反转，然后是以颜色和形状为无关线索的空间反转，然后是颜色反转，最后是形状反转。接触TCDD的猴子表现出对形状反转的学习迟缓。这种缺陷在过度训练后的第一次逆转中最为明显。在空间或颜色反转方面没有组间差异。然而，暴露于TCDD的猴子单独学习空间反转的试验次数与身体脂肪中的TCDD浓度呈正相关。相反，他们学习颜色反转的试验次数与身体脂肪中的TCDD呈负相关。
TCDD is an extremely toxic chemical pollutant which bioaccumulates in maternal adipose tissue, and is transferred to the developing organism during gestation and lactation. Long-term cognitive deficits have been reported followign perinatal exposure to polychlorinated biphenyls, which are structurally and toxicologically similar to TCDD. In the current study, monkeys exposed to TCDD perinatally were later tested in two cognitive paradigms, discrimination-reversal learning (RL) and delayed spatial alternation (DSA). RL detected effects; whereas DSA, as analyzed, did not. RL consisted of a series of simple spatial reversals, followed by spatial reversals with color and shape as irrelevant cues, then by color reversals and finally by shape reversals. TCDD-exposed monkeys exhibited retarded learning of the shape reversals. The deficit was most pronounced on the first reversal following overtraining. There were no group differences on the spatial or color reversals. However, the number of trials the TCDD-exposed monkeys individually took to learn the spatial reversals was positively correlated with TCDD concentration in body fat. Conversely, the number of trials they took to learn the color reversals was negatively correlated with TCDD in body fat.