COMMUNITY STUDY OF ROLE OF VIRAL-INFECTIONS IN EXACERBATIONS OF ASTHMA IN 9-11 YEAR-OLD CHILDREN
COMMUNITY STUDY OF ROLE OF VIRAL-INFECTIONS IN EXACERBATIONS OF ASTHMA IN 9-11 YEAR-OLD CHILDREN
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DOI：
10.1136/bmj.310.6989.1225
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发表时间：
1995-05-13
影响因子：
--
通讯作者：
HOLGATE, ST
中科院分区：
文献类型：
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作者：
JOHNSTON, SL;PATTEMORE, PK;HOLGATE, ST
研究社区学龄儿童上、下呼吸道病毒感染与哮喘急性加重之间的关系。设计-基于社区的13个月纵向研究，使用日记卡呼吸道症状和呼气峰流速监测，以允许病毒的早期采样。受试者-108名9-11岁的儿童，报告有喘息或咳嗽，或两者兼而有之，调查表中。设置-南安普敦和周围社区。主要结果测量-通过聚合酶链反应或常规方法检测的上呼吸道和下呼吸道病毒感染，报告的哮喘恶化，计算机识别呼吸道症状或峰值流量减少的发作。结果-在80%的报告的峰值呼气流量减少的发作中检测到病毒，80%报告的喘息发作，85%报告的上呼吸道症状发作，咳嗽，喘息和呼气峰流量下降。呼气峰流量福尔斯的中位持续时间为14天，呼气峰流量下降的中位最大值为81 1/min。最常见的病毒类型是rhinovirus. Conclusions-本研究支持这一假设，即上呼吸道病毒感染与学龄儿童哮喘急性发作的80-85%相关。
Objective-To study the association between upper and lower respiratory viral infections and acute exacerbations of asthma in schoolchildren in the community.Design-Community based 13 month longitudinal study using diary card respiratory symptom and peak expiratory flow monitoring to allow early sampling for viruses.Subjects-1O8 Children aged 9-11 years who had reported wheeze or cough, or both, in a questionnaire.Setting-Southampton and surrounding community.Main outcome measures-Upper and lower respiratory viral infections detected by polymerase chain reaction or conventional methods, reported exacerbations of asthma, computer identified episodes of respiratory tract symptoms or peak flow reductions.Results-Viruses were detected in 80% of reported episodes of reduced peak expiratory flow, 80% of reported episodes of wheeze, and in 85% of reported episodes of upper respiratory symptoms, cough, wheeze, and a fall in peak expiratory flow. The median duration of reported falls in peak expiratory flow was 14 days, and the median maximum fall in peak expiratory flow was 81 1/min. The most commonly identified virus type was rhinovirus.Conclusions-This study supports the hypothesis that upper respiratory viral infections are associated with 80-85% of asthma exacerbations in school age children.