Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve
Single session of brief electrical stimulation immediately following crush injury enhances functional recovery of rat facial nerve
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DOI：
10.1682/jrrd.2011.03.0033
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Jones, Kathryn J.
中科院分区：
文献类型：
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作者：
Foecking, Eileen M.;Fargo, Keith N.;Jones, Kathryn J.
周围神经损伤可导致多种病理状况，包括当损伤涉及运动轴突时的瘫瘫或瘫痪。我们一直在研究如何在面神经挤压损伤后使用每日电刺激（ES）来促进周围神经的再生。在我们之前的研究中，ES是在损伤后24小时才开始的。目前的实验测试了在挤压损伤后立即使用ES是否会进一步缩短面瘫完全恢复的时间。大鼠接受单侧面神经挤压损伤，电极放置在挤压部位近端的神经上。动物每天接受30分钟的ES治疗，持续1天（仅损伤当天）、2天、4天、7天或每天一次，直到功能完全恢复。未处理的动物没有ES。每天观察动物面部功能的恢复情况。我们的研究结果表明，在促进大多数功能参数的恢复方面，一次刺激与每日刺激一样有效。因此，在急性神经损伤导致的人类瘫痪患者中，应该研究使用单次30分钟的ES作为一种可能的治疗策略。
Peripheral nerve injuries lead to a variety of pathological conditions, including paresis or paralysis when the injury involves motor axons. We have been studying ways to enhance the regeneration of peripheral nerves using daily electrical stimulation (ES) following a facial nerve crush injury In our previous studies, ES was not initiated until 24 h after injury The current experiment tested whether ES administered immediately following the crush injury would further decrease the time for complete recovery from facial paralysis. Rats received a unilateral facial nerve crush injury and an electrode was positioned on the nerve proximal to the crush site. Animals received daily 30 min sessions of ES for 1 d (day of injury only), 2 d, 4 d, 7 d, or daily until complete functional recovery. Untreated animals received no ES. Animals were observed daily for the return of facial function. Our fmdings demonstrated that one session of ES was as effective as daily stimulation at enhancing the recovery of most functional parameters. Therefore, the use of a single 30 min session of ES as a possible treatment strategy should be studied in human patients with paralysis as a result of acute nerve injuries.