The Role of Human Parietal Area 7A as a Link between Sequencing in Hand Actions and in Overt Speech Production
The Role of Human Parietal Area 7A as a Link between Sequencing in Hand Actions and in Overt Speech Production
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人类顶叶 7A 区作为手部动作排序和公开言语产生之间联系的纽带
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
S. Eickhoff
中科院分区：
文献类型：
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作者：
S. Heim;K. Amunts;Tanja Hensel;Marion Grande;W. Huber;F. Binkofski;S. Eickhoff
对人类语言能力进化基础的研究已经提出镜像神经元系统是运动加工和语言发展之间的纽带。因此，大多数研究都集中在左侧额下皮层，特别是布罗卡区和左侧顶叶下皮层。然而，手部运动规划与言语行为之间的直接联系尚未得到阐明。因此，本研究调查了手和语言动作的运动排序是否有一个共同的神经分母。对于手部运动任务，25名受试者用左手或右手进行单次、重复或顺序的按钮按压。演讲任务是类比的；同样的主语一次或多次发出音节“po”，或者一系列不同的音节（“po-pi-po”）。语言运动与手部运动效应导致包括布洛卡区（左44区和左45区中间邻近区域）在内的外围激活增加。相比之下，对序列和重复按键和音节产生的共同激活表明，顶叶上小叶（SPL）左7A区参与序列的效应不依赖。这些数据表明，语音手势的排序是有序话语和最终人类语言的重要先决条件，作为一个共同的皮层模块，它与手部运动排序共享7A区，而不是下顶叶区。有趣的是，7A区先前也被证明与观察手部和非手部动作有关。结合文献，目前的数据因此表明了44区（专门用于言语的认知方面）和SPL 7A区（用于运动排序的一般方面）之间的区别。综上所述，本研究揭示了SPL在言语起源中的作用，并且可以从言语和语言在运动系统中的体现角度进行讨论。
Research on the evolutionary basis of the human language faculty has proposed the mirror neuron system as a link between motor processing and speech development. Consequently, most work has focused on the left inferior frontal cortex, in particular Broca’s region, and the left inferior parietal cortex. However, the direct link between planning of hand motor and speech actions has yet to be elucidated. Thus, the present study investigated whether motor sequencing of hand vs. speech actions has a common neural denominator. For the hand motor task, 25 subjects performed single, repeated, or sequenced button presses with either the left or right hand. The speech task was in analogy; the same subjects produced the syllable “po” once or repeatedly, or a sequence of different syllables (“po-pi-po”). Speech motor vs. hand motor effectors resulted in increased perisylvian activation including Broca’s region (left area 44 and areas medially adjacent to left area 45). In contrast, common activation for sequenced vs. repeated production of button presses and syllables revealed the effector-independent involvement of left area 7A in the superior parietal lobule (SPL) in sequencing. These data demonstrate that sequencing of vocal gestures, an important precondition for ordered utterances and ultimately human speech, shares area 7A, rather than inferior parietal regions, as a common cortical module with hand motor sequencing. Interestingly, area 7A has previously also been shown to be involved in the observation of hand and non-hand actions. In combination with the literature, the present data thus suggest a distinction between area 44, which is specifically recruited for (cognitive aspects of) speech, and SPL area 7A for general aspects of motor sequencing. In sum, the study demonstrates a previously underspecified role of the SPL in the origins of speech, and may be discussed in the light of embodiment of speech and language in the motor system.