Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma
Increased serum autotaxin levels in hepatocellular carcinoma patients were caused by background liver fibrosis but not by carcinoma
复制标题
DOI：
10.1016/j.cca.2014.03.006
复制
发表时间：
2014-06-10
影响因子：
5
通讯作者：
Ikeda, Hitoshi
中科院分区：
文献类型：
--
作者：
Kondo, Mayuko;Ishizawa, Takeaki;Ikeda, Hitoshi
背景资料：自分泌运动因子（autotaxin，ATX）是否与肝细胞癌（hepatocellular carcinoma，HCC）的病理生理学相关存在争议。方法：我们连续检测了148例接受射频消融（radiofrequency ablation，RFA）治疗的HCC患者和30例肝切除患者的血清ATX水平及其mRNA表达。尽管在几乎所有接受RFA治疗的患者中观察到血清ATX水平升高，但RFA后未降低。此外，血清ATX水平与肿瘤负荷无关，但与预测肝纤维化的参数相关，如肝硬度值。然后，在接受化疗的患者中，血清ATX水平与HCC组织中ATX mRNA表达水平之间没有显著相关性。值得注意的是，ATXmRNA在HCC组织中的表达水平并不高于癌周组织。最后，血清ATX水平在化疗治疗肝癌患者，而与ATXmRNA表达水平在癌周组织以及肝纤维化stage.Conclusion：在肝癌患者血清ATX水平的增加可能不是由丰富的ATX生产在肝癌组织，但在背景肝纤维化。(C)© 2014 Elsevier B.V.保留所有权利。
Background: Controversy exists as to whether autotaxin (ATX) may be importantly associated with pathophysiology of hepatocellular carcinoma (HCC).Methods: We evaluated serum ATX levels and its mRNA expression in consecutive 148 HCC patients treated with radiofrequency ablation (RFA) and 30 patients with hepatic resection.Results: Although increased serum ATX levels were observed in almost all the patients treated with RFA, they were not reduced after RFA. Furthermore, serum ATX levels were associated not with tumor burden but with the parameters predicting for liver fibrosis, such as liver stiffness values. Then, in surgically-treated patients, there was no significant correlation between serum ATX levels and ATX mRNA expression levels in HCC tissues. Notably, ATXmRNA expression levels in HCC tissues were not higher than those in peri-tumorous tissues. Finally, serum ATX levels in surgically-treated HCC patients were rather correlated with ATX mRNA expression levels in peri-tumorous tissues as well as with liver fibrosis stage.Conclusion: The increase in serum ATX levels in HCC patients may not be caused by abundant ATX production in HCC tissues but by fibrosis in the background livers. (C) 2014 Elsevier B.V. All rights reserved.