Impaired response inhibition function in abstinent heroin dependents: An fMRI study
Impaired response inhibition function in abstinent heroin dependents: An fMRI study
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DOI：
10.1016/j.neulet.2008.04.033
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发表时间：
2008-06-27
影响因子：
2.5
通讯作者：
Yang, Zheng
中科院分区：
文献类型：
--
作者：
Fu, Li-ping;Bi, Guo-hua;Yang, Zheng
海洛因与其他违禁物质一样，反复滥用后对额叶认知功能产生负面影响。我们使用功能性磁共振成像（fMRI）检查的反应抑制和竞争的神经基板在18个健康对照和评估额叶神经认知在30个戒毒海洛因依赖者（AHD），因为他们进行了一个去/不去协会任务的反应时自发记录。由反应抑制引起的神经反应主要集中在中线结构，特别是双侧内侧前额叶回和前扣带回，以及左侧额中回、额中回、双侧额下回和边缘系统。与未用药对照组不同，AHD组仅激活双侧额上级回和左侧额中回。此外，AHD的RT显著长于对照组。结果表明：（1）ACC、mPFC和下额叶在反应抑制和竞争中起重要作用;（2）海洛因依赖者反应抑制功能受损持续至戒断后数月，表明海洛因对反应抑制功能的负面影响在早期持久戒断状态下仍在持续。(c)2008爱思唯尔爱尔兰有限公司保留所有权利。
Heroin, like various illicit substances, has a negative impact on the frontal cognitive function after repeated abuse. We used functional magnetic resonance imaging (fMRI) to examine the neural substrates of response inhibition and competition in 18 healthy controls and assess the frontal neurocognition in 30 abstinent heroin dependents (AHD) as they performed a Go/NoGo Association task with reaction times recorded spontaneously. The neural response which was induced by response inhibition was prominent in the midline structure, specifically the bilateral medial prefrontal gyrus and anterior cingulated cortex, as well as the left middle frontal gyrus, insula, bilateral inferior frontal gyrus and limbic system. Unlike drug-naive controls, only the bilateral superior frontal gyrus and left middle frontal gyrus were activated in AHD. Furthermore, the RT of AHD was significantly longer than that of controls. The results suggest that: (1) the ACC, mPFC and inferior frontal lobe play an important role in response inhibition and competition; (2) heroin dependents had an impaired response inhibition function that lasted even months into abstinence, which indicates that the negative effect of heroin on the inhibitory function still continues in early protracted withdrawal state. (c) 2008 Elsevier Ireland Ltd. All rights reserved.