Age-related brain changes associated with motor function in healthy older people
Age-related brain changes associated with motor function in healthy older people
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DOI：
10.1111/j.1532-5415.1999.tb02997.x
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发表时间：
1999-03-01
影响因子：
6.3
通讯作者：
Kaye, JA
中科院分区：
文献类型：
--
作者：
Camicioli, R;Moore, MM;Kaye, JA
目的：目的：明确健康老年人运动功能改变的MRI影像学表现，设计：横断面研究，地点：俄勒冈州脑老化研究，研究健康老年人的神经功能（平均年龄= 85.1岁，标准差= 7.2岁）。临床措施（手指敲击，手打开和关闭，步数和步行30英尺的时间以及站立一英尺的时间）是多元回归分析中的因变量，使用年龄和以下MRI测量值作为自变量：结果：行走步数和行走30英尺的时间均与脑室周围高信号有关（步长：r = .58，P < .001;时间：r = .60，P < .001）和心室容积（步长：r = .54，P < .001;时间：r = .58，P < .001）。这些关联在调整年龄后仍然显着。没有其他临床变量与MRI volumes.CONCLUSIONS：步态措施与脑室周围高信号和心室容积显着相关。这些中枢神经系统的变化有助于这些重要的衰老标志物的原因。
OBJECTIVE: To identify the MRI imaging findings associated with motor changes in healthy older people,DESIGN: A cross-sectional study.SETTING: A study of neurologic function in very healthy older people, the Oregon Brain Aging Study.PARTICIPANTS: Clinical and MRI data were examined in 50 very healthy older subjects (mean age = 85.1, SD = 7.2 years).MEASUREMENTS: Clinical measures (finger tapping, hand opening and closing, steps and time to walk 30 feet and timed standing an one foot) were dependent variables in multiple regression analyses using age and the following MRI measures as independent variables: total brain volume (TBV)/intracranial volume; ventricular volume/TBV; periventricular high signal/TBV; deep high signal/TBV.RESULTS: The number of steps and the time to walk 30 feet were each associated with periventricular high signal (steps: r = .58, P < .001; time: r = .60, P < .001) and ventricular volume (steps: r = .54, P < .001; time: r = .58, P < .001). These associations remained significant after adjusting for age. None of the other clinical variables was associated with the MRI volumes.CONCLUSIONS: Gait measures were associated significantly with periventricular high signal and ventricular volume. These CNS changes contribute to the cause of these important markers of aging.