Period-independent novel circadian oscillators revealed by timed exercise and palatable meals.
Period-independent novel circadian oscillators revealed by timed exercise and palatable meals.
复制标题
DOI：
10.1038/srep21945
复制
发表时间：
2016-02-24
影响因子：
4.6
通讯作者：
Yamazaki S
中科院分区：
文献类型：
--
作者：
Flôres DE;Bettilyon CN;Yamazaki S
哺乳动物的昼夜节律系统是一个层次网络的振荡器组织，以最佳地协调行为和生理与日常环境周期。下丘脑的视交叉上核（SCN）位于这个层次的顶端，与环境的明暗周期同步，并协调外周时钟的相位。周期基因是这些时钟的分子计时机制的关键组成部分。在周期1/2/3三重突变小鼠中，生物钟被禁用，导致在恒定条件下的运动行为。我们通过简单地让老鼠定时吃一顿可口的饭或跑步来发现这种突变体的节律行为。在没有周期性环境线索的恒定条件下，突发性昼夜节律节律自由运行许多周期。总之，这些数据表明，可口的膳食诱导的昼夜节律振荡器（皮科）和车轮诱导的昼夜节律振荡器（WICO）产生的非规范的昼夜节律钟。通过可口的零食和定时运动来吸引这些新的振荡器，可能会成为治疗生物钟紊乱引起的人类疾病的新疗法。
The mammalian circadian system is a hierarchical network of oscillators organized to optimally coordinate behavior and physiology with daily environmental cycles. The suprachiasmatic nucleus (SCN) of the hypothalamus is at the top of this hierarchy, synchronizing to the environmental light-dark cycle, and coordinates the phases of peripheral clocks. The Period genes are critical components of the molecular timekeeping mechanism of these clocks. Circadian clocks are disabled in Period1/2/3 triple mutant mice, resulting in arrhythmic behavior in constant conditions. We uncovered rhythmic behavior in this mutant by simply exposing the mice to timed access to a palatable meal or running wheel. The emergent circadian behavior rhythms free-ran for many cycles under constant conditions without cyclic environmental cues. Together, these data demonstrate that the palatable meal-inducible circadian oscillator (PICO) and wheel-inducible circadian oscillator (WICO) are generated by non-canonical circadian clocks. Entrainment of these novel oscillators by palatable snacks and timed exercise could become novel therapeutics for human conditions caused by disruptions of the circadian clocks.