Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer's disease.
Attention-deficit/hyperactivity disorder in childhood is associated with cognitive test profiles in the geriatric population but not with mild cognitive impairment or Alzheimer's disease.
复制标题
儿童期的注意力缺陷/多动症障碍与老年人群的认知测试概况有关，但与轻度认知障碍或阿尔茨海默氏病无关。
DOI：
10.4061/2011/729801
复制
发表时间：
2011
影响因子：
4.7
通讯作者：
Jicha GA
中科院分区：
文献类型：
--
作者：
Ivanchak N;Abner EL;Carr SA;Freeman SJ;Seybert A;Ranseen J;Jicha GA
ADHD在老年人群中的频率及其与晚年认知能力下降的关系以前没有研究过。为了解决我们理解中的这一差距，Wender-Utah ADHD评定量表（WURS）对310名认知状态从正常认知到轻度认知障碍到明显痴呆的老年受试者进行了评估。在这个样本中，WURS阳性ADHD的频率为4.4%。WURS评分与认知诊断无关，但与需要持续注意的任务存在非线性关联。ADHD的频率在几代人之间似乎是稳定的，似乎与MCI或痴呆诊断无关。老年受试者的注意力处理缺陷和WURS分数的关联可能表明，这些特征在整个生命中保持稳定。在解释表现出ADHD体征和症状的老年人群的认知测试特征时应谨慎，因为注意力缺陷可能不一定意味着存在潜在的神经退行性疾病状态。
The frequency of ADHD in the aging population and its relationship to late-life cognitive decline has not been studied previously. To address this gap in our understanding, the Wender-Utah ADHD Rating scale (WURS) was administered to 310 geriatric subjects with cognitive status ranging from normal cognition to mild cognitive impairment to overt dementia. The frequency of WURS-positive ADHD in this sample was 4.4%. WURS scores were not related to cognitive diagnoses, but did show nonlinear associations with tasks requiring sustained attention. The frequency of ADHD appears stable across generations and does not appear to be associated with MCI or dementia diagnoses. The association of attentional processing deficits and WURS scores in geriatric subjects could suggest that such traits remain stable throughout life. Caution should be considered when interpreting cognitive test profiles in the aging population that exhibit signs and symptoms of ADHD, as attentional deficits may not necessarily imply the existence of an underlying neurodegenerative disease state.