High-normal HbA1c is a strong predictor of type 2 diabetes in the general population.
High-normal HbA1c is a strong predictor of type 2 diabetes in the general population.
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DOI：
10.2337/dc10-1180
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发表时间：
2011-04
期刊：
影响因子：
16.2
通讯作者：
Willeit J
中科院分区：
文献类型：
--
作者：
Bonora E;Kiechl S;Mayr A;Zoppini G;Targher G;Bonadonna RC;Willeit J
美国糖尿病协会最近推荐糖化血红蛋白（HbA1c）用于糖尿病的诊断，但其在预测2型糖尿病方面的价值却知之甚少。在这项研究中，我们评估了正常高值 HbA1c 水平如何预测 2 型糖尿病。我们测量了 919 名年龄在 40-79 岁的白人受试者中的 HbA1c，并记录了接下来 15 年中 2 型糖尿病的新病例。通过 HbA1c 诊断糖尿病。根据基线 HbA1c（<5.0、5.00–5.49 [参考]、5.50–5.99 和 6.00–6.49%）对受试者进行分层。 2 型糖尿病的性别和年龄调整风险比 (95% CI) 分别为 1.11 (0.30–4.41)、1.00、3.79 (1.79–8.06) 和 12.50 (5.51–28.34)。在调整了几个假定的混杂因素后，结果没有变化，并且在使用具有更新变量的模型时得到了证实。 HbA1c 是 2 型糖尿病的独立危险因素。 HbA1c 处于正常高水平的受试者值得特别关注，因为他们患糖尿病的风险很高。
Glycosylated hemoglobin (HbA1c) recently has been recommended for the diagnosis of diabetes by the American Diabetes Association, but its value in the prediction of type 2 diabetes is poorly understood. In this study we evaluated how high-normal HbA1c levels predict type 2 diabetes. We measured HbA1c in 919 Caucasian subjects, aged 40–79 years, and recorded new cases of type 2 diabetes in the following 15 years. Diabetes was diagnosed with HbA1c. Subjects were stratified according to baseline HbA1c (<5.0, 5.00–5.49 [reference], 5.50–5.99, and 6.00–6.49%). Sex- and age-adjusted hazard ratios (95% CI) for type 2 diabetes were 1.11 (0.30–4.41), 1.00, 3.79 (1.79–8.06), and 12.50 (5.51–28.34), respectively. Results did not change after adjusting for several putative confounding factors and were confirmed when models with updated variables were used. HbA1c is an independent risk factor for type 2 diabetes. Subjects with high-normal levels of HbA1c deserve particular attention because they have a strong risk of developing diabetes.
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影响因子：
16.2
作者：
通讯作者：
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DOI：
10.1056/nejmoa0908359
发表时间：
2010-03-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Selvin E;Steffes MW;Zhu H;Matsushita K;Wagenknecht L;Pankow J;Coresh J;Brancati FL
通讯作者：
Brancati FL
影响因子：
5.9
作者：
Pradhan, Aruna D.;Rifai, Nader;Ridker, Paul M.
通讯作者：
Ridker, Paul M.
影响因子：
7.7
作者：
Bonora, E;Kiechl, S;Muggeo, M
通讯作者：
Muggeo, M
影响因子：
--
作者：
Selvin, Elizabeth;Crainiceanu, Ciprian M.;Coresh, Josef
通讯作者：
Coresh, Josef