The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD
The effect of eicosapentaenoic acid on renal function and volume in patients with ADPKD
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DOI：
10.1093/ndt/gfn144
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发表时间：
2008-09-01
影响因子：
6.1
通讯作者：
Hamazaki, Tomohito
中科院分区：
文献类型：
--
作者：
Higashihara, Eiji;Nutahara, Kikuo;Hamazaki, Tomohito
背景。大豆蛋白改善大鼠多囊肾病伴肾富集的- 3-多不饱和脂肪酸。本研究探讨了二十碳五烯酸（EPA）对常染色体显性多囊肾病（ADPKD）患者肾脏容量和功能的影响。非氮化患者随机分为对照组（n = 20）和EPA组（n = 21）。EPA组给予EPA胶囊（2.4 g/d），疗程2年。每年收集24小时尿液进行肌酐清除率（Ccr）测定。在基线和24个月时，测量红细胞中的脂肪酸组成，并通过改进的椭球法和体积法获得计算机断层扫描计算肾脏体积。EPA组红细胞中EPA浓度（1.80 +/- 0.99比4.40 +/- 1.79面积%，P < 0.001）和omega 3/omega 6比值升高，二十二碳六烯酸（DHA）浓度（6.76 +/- 1.19比5.64 +/- 1.45面积%，P < 0.010）降低。对照组和EPA组Ccr分别降低8.5 +/- 9.5和9.0 +/- 13.0 ml/min/1.73 m(2)/2年（NS）。两组间两种方法计算的肾容积增加量无显著差异。EPA对ADPKD患者肾功能和肾体积的有益作用在本研究中尚未得到证实。为了证明omega - 3多不饱和脂肪酸对ADPKD进展的预防作用，EPA和DHA补充和/或更长时间的干预可能是必要的。
Background. Soy protein ameliorates rat polycystic kidney disease with concomitant renal enrichment of omega 3-polyunsaturated fatty acids. A study was conducted to examine the effects of eicosapentaenoic acids (EPA) on renal volume and function in patients with autosomal dominant polycystic kidney disease (ADPKD).Methods. Non-azotemic patients were randomized to either a control group (n = 20) or an EPA group (n = 21). EPA capsules (2.4 g/day) were administered in the EPA group for 2 years. Twenty-four hours of urine was collected for the creatinine clearance (Ccr) measurement every year. At baseline and 24 months, fatty acid compositions in erythrocytes were measured and computerized tomographies were obtained for calculation of renal volume by the modified ellipsoid and volumetric methods.Results. In the EPA group, the EPA concentration (1.80 +/- 0.99 versus 4.40 +/- 1.79 area%, P < 0.001) and the (omega 3/omega 6 ratio in the erythrocyte increased, but docosahexaenoic acid (DHA) (6.76 +/- 1.19 versus 5.64 +/- 1.45 area%, P < 0.010) concentration decreased. Ccr decreased by 8.5 +/- 9.5 and 9.0 +/- 13.0 ml/min/1.73 m(2)/2 years in the control and EPA groups, respectively (NS). The increases in renal volume calculated by either method were not significantly different between the two groups.Conclusions. A beneficial effect of EPA on renal function and kidney volume in ADPKD patients could not be confirmed in the present study. Administration of EPA with DHA supplementation and/or longer intervention might be necessary to demonstrate preventive effects of omega 3-polyunsaturated fatty acids on progression of ADPKD.