Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family
Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family
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DOI：
10.1016/s0165-6147(02)00038-x
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发表时间：
2003-02-01
影响因子：
13.8
通讯作者：
Burnstock, G
中科院分区：
文献类型：
--
作者：
Abbracchio, MP;Boeynaems, JM;Burnstock, G
最近报道了对UDP-葡萄糖和相关糖-核苷酸特异性应答的人G蛋白偶联受体（GPCR）的克隆。该受体与P2 Y受体家族的已知成员具有重要的结构相似性，但也显示出明显不同的药理学反应特征。在这里，IUPHAR P2 Y受体命名和分类小组委员会回顾了目前对这种受体的认识，并提出了将这种受体作为P2 Y（14）受体纳入P2 Y受体家族的理由。
The cloning of a human G-protein-coupled receptor (GPCR) that specifically responds to UDP-glucose and related sugar-nucleotides has been reported recently. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological response profile. Here, the IUPHAR Subcommittee for P2Y receptor nomenclature and classification review the current knowledge of this receptor and present their reasons for including this receptor in the P2Y receptor family as the P2Y(14) receptor.