Smoking induced heavy metals and periodontitis: findings from the Korea National Health and Nutrition Examination Surveys 2008-2010
Smoking induced heavy metals and periodontitis: findings from the Korea National Health and Nutrition Examination Surveys 2008-2010
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DOI：
10.1111/jcpe.12133
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发表时间：
2013-09-01
影响因子：
6.7
通讯作者：
Lim, Sinye
中科院分区：
文献类型：
--
作者：
Han, Dong-Hun;Lee, Hye-Ju;Lim, Sinye
目的：暴露于镉和铅等有害重金属可能会导致牙周组织中氧化应激和炎症的增加。我们的目的是评估血清镉和铅水平和牙周炎之间的关联。材料与方法：汇总的横截面数据，从韩国国家健康和营养检查调查2008-2010年。牙周炎定义为WHO社区牙周指数。主动吸烟者定义为自我报告的当前吸烟者或尿可替宁测量值164 ng/ml的人。采用石墨炉原子吸收光谱法测定血清镉、铅水平。多元Logistic回归分析用于估计牙周炎的优势比（OR）。结果：牙周炎组的平均镉和铅水平显著高于对照组。血清重金属含量随着牙周炎的发生而逐渐升高。牙周炎的OR值与血清镉（OR = 1.37; 95%CI 1.00-1.87）和铅（OR = 1.60; 95%CI 1.15-2.21）水平显著相关。调整血清镉浓度后，牙周炎和吸烟之间的关联减弱。结论：我们证明了牙周炎和血清镉和铅浓度之间的显着关联。镉似乎部分介导吸烟和牙周炎之间的关联。
Aim: Exposure to hazardous heavy metals such as cadmium and lead may contribute to increased oxidative stress and inflammation in the periodontal tissue. We aimed to evaluate the association between serum cadmium and lead levels and periodontitis.Materials & Methods: Pooled cross-sectional data from the Korea National Health and Nutrition Examination Surveys 2008-2010 were used. Periodontitis was defined as WHO community periodontal index. Active smokers were defined as self-reported current smokers or those with measured urine cotinine 164ng/ml measurements. Serum cadmium and lead levels were measured using graphite furnace atomic absorption spectrometry. Multiple logistic regression analysis was used to estimate the odds ratios (OR) for periodontitis.Results: The mean cadmium and lead levels were significantly higher in the periodontitis group compared with control population. A progressive increase in serum heavy metals were found as the number of sextants with periodontitis. The ORs for periodontitis were significantly associated with serum cadmium (OR = 1.37; 95% CI 1.00-1.87) and lead levels (OR = 1.60; 95% CI 1.15-2.21). The association between periodontitis and smoking was attenuated after adjusting for serum cadmium concentration.Conclusions: We demonstrated a significant association between periodontitis and serum cadmium and lead concentrations. Cadmium appeared to partially mediate the association between smoking and periodontitis.