Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia.
Effect of Serum Leptin on Weight Gain Induced by Olanzapine in Female Patients with Schizophrenia.
复制标题
血清瘦素对奥氮平诱导的精神分裂症患者诱导的体重增加的影响。
DOI：
10.1371/journal.pone.0149518
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Someya T
中科院分区：
文献类型：
--
作者：
Tsuneyama N;Suzuki Y;Sawamura K;Sugai T;Fukui N;Watanabe J;Ono S;Saito M;Someya T
奥氮平（OLZ）治疗与体重增加的高风险相关，并可能导致糖脂代谢异常。因此，OLZ相关体重增加的潜在机制需要澄清，但尚未充分确定。近年来，脂肪细胞因子如瘦素、脂联素和肿瘤坏死因子（TNF）-α等在能量平衡中发挥重要作用，被认为是体重增加的生物标志物。在此，我们确定了基线血浆瘦素、脂联素和TNF-α浓度是否能预测OLZ治疗后体重增加。我们招募了31名门诊精神分裂症患者（12名男性和19名女性，28.8 ± 10.2岁），他们未接受药物治疗或接受其他抗精神病药物单药治疗。获得基线体重指数（BMI）和血浆瘦素、脂联素和TNF-α水平。所有患者开始或转换为OLZ单药治疗最长1年。还在终点时获得BMI。OLZ治疗后的平均BMI变化为2.1 ± 2.7 kg/m2。在女性患者中，BMI从基线到终点的变化与基线瘦素水平呈负相关（r =-0.514，P = 0.024），但与男性患者无关。基线脂联素或TNF-α水平与BMI变化无关。女性精神分裂症患者接受OLZ治疗后，基线血浆瘦素可对随后的体重增加产生影响。
Olanzapine (OLZ) treatment is associated with a high risk of weight gain, and may cause abnormalities in glycolipid metabolism. Therefore, the underlying mechanism of OLZ-related weight gain is needed to clarify but not yet been adequately determined. In recent years, adipocytokines such as leptin, adiponectin, and tumor necrosis factor (TNF)-α, which play important roles in energy homeostasis, have been suggested as biomarkers of weight gain. Here, we determined if baseline plasma concentrations of leptin, adiponectin, and TNF-α predict weight gain following OLZ treatment. We recruited 31 schizophrenia outpatients (12 men and 19 women, 28.8 ± 10.2 years old) that were unmedicated or on another antipsychotic monotherapy medication. Baseline body mass index (BMI) and plasma levels of leptin, adiponectin, and TNF-α were obtained. All patients started or were switched to OLZ monotherapy for a maximum of 1 year. BMI was also obtained at the endpoint. Mean BMI change following OLZ treatment was 2.1 ± 2.7 kg/m2. BMI change from baseline to endpoint negatively-correlated with baseline leptin levels in female patients (r = −0.514, P = 0.024), but not male patients. Baseline adiponectin or TNF-α levels were not correlated with BMI change. Baseline plasma leptin can have an effect on subsequent weight gain following OLZ treatment in female patients with schizophrenia.