HLA typing of a Hong Kong Chinese family with intermediate uveitis
HLA typing of a Hong Kong Chinese family with intermediate uveitis
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DOI：
10.1136/bjo.2005.088658
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发表时间：
2006-05-01
影响因子：
4.1
通讯作者：
Amoaku, WM
中科院分区：
文献类型：
--
作者：
Browning, AC;Calladine, D;Amoaku, WM
中间葡萄膜炎（IU）是一种潜在的视力威胁的条件下看到的所有种族群体。由于自身免疫可能在疾病的发病机制中起作用，工作人员研究了非家族性IU的免疫遗传学，并提出了某些HLA等位基因的作用，如HLA-A* 28、HLA-DRB 1 * 15、HLA-B * 51、HLA-B * 52、HLA-B * 53、HLA-B * 54、HLA-B* 55、HLA-B* 56、HLA-B* 57、HLA-B* 58、HLA-B* 59、HLA-和B* 08在促进主要为白色人群对该病症的易感性方面的作用。1-5虽然IU是葡萄膜炎诊所中相对常见的诊断，占所有葡萄膜炎病例的15%，但文献中很少有家族性病例的报道。在这项研究中，确定了一个香港华人家庭，其中一些成员一直在英国三级转诊中心的葡萄膜炎诊所就诊。
Intermediate uveitis (IU) is a potentially sight threatening condition seen in all racial groups. While the disorder is known to be associated with a number of systemic conditions, in the majority of cases, no underlying cause is found. Because autoimmunity may play a part in the pathogenesis of the disease, workers have studied the immunogenetics of non-familial IU and have suggested a role for certain HLA alleles such as HLA-A* 28 HLADRB1* 15, HLA-B* 51, and B* 08 in promoting susceptibility to the condition in predominantly white populations. 1–5 While IU is a relatively common diagnosis in a uveitis clinic, constituting up to 15% of all uveitis cases seen, 6 there are few reports in the literature of familial cases. In this study, a Hong Kong Chinese family was identified, some members of who had been attending the uveitis clinic at a tertiary referral centre in the United Kingdom with IU.