The Transcriptome of Latent Human Cytomegalovirus
The Transcriptome of Latent Human Cytomegalovirus
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DOI：
10.1128/jvi.00047-19
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发表时间：
2019-03
影响因子：
5.4
通讯作者：
M. Schwartz;Noam Stern-Ginossar
中科院分区：
文献类型：
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作者：
M. Schwartz;Noam Stern-Ginossar
由于天然潜伏细胞的稀缺性和可用模型的复杂性，潜伏的人巨细胞病毒（HCMV）转录组一直非常难以定义。基因组时代提供了许多转录组分析的方法，这些方法具有阐明这一具有挑战性的问题的巨大潜力。摘要由于天然潜伏细胞的缺乏和现有模型的复杂性，潜伏的人巨细胞病毒（HCMV）转录组的定义一直非常困难。基因组时代提供了许多转录组分析方法，这些方法对于阐明这一具有挑战性的问题具有巨大潜力。最近的两项研究应用不同的转录组学方法和实验和自然样本的分析结果挑战了限制性潜伏期相关转录程序的教条。相反，他们将HCMV潜伏感染的标志描绘为广谱典型病毒裂解基因的低水平表达。
The latent human cytomegalovirus (HCMV) transcriptome has been extremely difficult to define due to the scarcity of naturally latent cells and the complexity of available models. The genomic era offers many approaches to transcriptome profiling that hold great potential for elucidating this challenging issue. ABSTRACT The latent human cytomegalovirus (HCMV) transcriptome has been extremely difficult to define due to the scarcity of naturally latent cells and the complexity of available models. The genomic era offers many approaches to transcriptome profiling that hold great potential for elucidating this challenging issue. The results from two recent studies applying different transcriptomic methodologies and analyses of both experimental and natural samples challenge the dogma of a restricted latency-associated transcription program. Instead, they portray the hallmark of HCMV latent infection as low-level expression of a broad spectrum of canonical viral lytic genes.