MRI characterization of brown adipose tissue in obese and normal-weight children
MRI characterization of brown adipose tissue in obese and normal-weight children
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DOI：
10.1007/s00247-015-3391-z
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发表时间：
2015-10-01
影响因子：
2.3
通讯作者：
Josefson, Jami L.
中科院分区：
文献类型：
--
作者：
Deng, Jie;Schoeneman, Samantha E.;Josefson, Jami L.
棕色脂肪组织（BAT）是哺乳动物体内调节能量消耗和产热的适应性产热器官。人类BAT可能主要由白色中的棕色（BRITE）脂肪细胞组成，并且BRITE的刺激可以用作肥胖干预的潜在靶标。BAT检测和表征的当前成像研究主要限于PET/CT。MRI是一种新兴的BAT表征在健康儿童中的应用。为了利用狄克逊和弥散加权MRI方法来表征正常体重和肥胖儿童的颈部锁骨上BAT/BRITE特性，同时考虑青春期状态。28名体重指数正常或肥胖的健康儿童（9-15岁）参加了研究。进行MRI检查，通过测量组织脂肪百分比、T2*、组织水流动性和微血管特性来表征锁骨上脂肪组织。我们使用多变量线性回归模型比较正常体重和肥胖组的组织特性，同时考虑青春期状态。与正常体重儿童相比，肥胖儿童BAT/BRITE组织的MRI测量显示较高的脂肪百分比（P <0.0001），较高的T2*（P < 0.0001）和较低的扩散系数（P = 0.015）。青春期状态是T2* 测量的显著协变量，青春期儿童的T2*（P = 0.0087）高于青春期前儿童。灌注测量值因青春期状态而异。与正常体重儿童相比，青春期前肥胖儿童的灌注分数较低（P = 0.003）和假灌注系数（P = 0.048）;但是，在此情况下，青春期肥胖儿童的血流灌注分数（P = 0.02）和假灌注系数该研究利用化学位移狄克逊MRI和扩散加权MRI方法来表征锁骨上BAT/BRITE组织特性。多参数评估揭示了肥胖和正常体重儿童棕色脂肪组织形态学差异的证据。
Brown adipose tissue (BAT) is identified in mammals as an adaptive thermogenic organ for modulation of energy expenditure and heat generation. Human BAT may be primarily composed of brown-in-white (BRITE) adipocytes and stimulation of BRITE may serve as a potential target for obesity interventions. Current imaging studies of BAT detection and characterization have been mainly limited to PET/CT. MRI is an emerging application for BAT characterization in healthy children.To exploit Dixon and diffusion-weighted MRI methods to characterize cervical-supraclavicular BAT/BRITE properties in normal-weight and obese children while accounting for pubertal status.Twenty-eight healthy children (9-15 years old) with a normal or obese body mass index participated. MRI exams were performed to characterize supraclavicular adipose tissues by measuring tissue fat percentage, T2*, tissue water mobility, and microvasculature properties. We used multivariate linear regression models to compare tissue properties between normal-weight and obese groups while accounting for pubertal status.MRI measurements of BAT/BRITE tissues in obese children showed higher fat percentage (P < 0.0001), higher T2* (P < 0.0001), and lower diffusion coefficient (P = 0.015) compared with normal-weight children. Pubertal status was a significant covariate for the T2* measurement, with higher T2* (P = 0.0087) in pubertal children compared to prepubertal children. Perfusion measurements varied by pubertal status. Compared to normal-weight children, obese prepubertal children had lower perfusion fraction (P = 0.003) and pseudo-perfusion coefficient (P = 0.048); however, obese pubertal children had higher perfusion fraction (P = 0.02) and pseudo-perfusion coefficient (P = 0.028).This study utilized chemical-shift Dixon MRI and diffusion-weighted MRI methods to characterize supraclavicular BAT/BRITE tissue properties. The multi-parametric evaluation revealed evidence of morphological differences in brown adipose tissues between obese and normal-weight children.