Dual double arterial phase dynamic MR imaging with sensitivity encoding (SENSE): which is better for diagnosing hypervascular hepatocellular carcinomas, in-phase or opposed-phase imaging?
Dual double arterial phase dynamic MR imaging with sensitivity encoding (SENSE): which is better for diagnosing hypervascular hepatocellular carcinomas, in-phase or opposed-phase imaging?
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DOI：
10.1016/j.mri.2004.01.010
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发表时间：
2004-04-01
影响因子：
2.5
通讯作者：
Itai, Y
中科院分区：
文献类型：
--
作者：
Yoshioka, H;Sato, J;Itai, Y
本研究的目的是探讨灵敏度编码（SENSE）动态磁共振成像（MRI）与双（同相和反相）双动脉期检测富血供肝细胞癌（HCC）的有效性。获得了44例连续患者的肝脏MR图像。使用梯度回波序列（TR/TE/翻转角= 168/2.3和4.6/70），在每次扫描11 s时进行6次（造影前、早期动脉、晚期动脉、造影剂注射后1 min、3 min和5 min）SENSE动态MRI。每次扫描同时获得同相和反相图像。在定量分析方面，分析了55例HCC的信噪比（S/N）和肿瘤与肝脏的对比噪声比（C/N）。在所有时相，同相图像上的肝癌平均S/N值均显着高于反相图像上的平均S/N值（P < 0.001）。在动脉期。同相位图像的平均肿瘤/肝脏C/N值显著高于反相位图像（P < 0.05）。在射野和延迟相位图像中。在反相图像中，平均肿瘤-肝脏C/N显示为负值。在6例脂肪变性的肝癌中，动脉期图像上肿瘤与肝脏的平均C/N在反相时接近于零，而在同相时显示为正值。在肝脏双动脉期动态MRI中，同相图像在检测富血供HCC的早期增强方面上级反相图像，而后者在检测门脉期和延迟期HCC的造影剂洗脱方面上级反相图像。这两种图像的结合克服了诊断脂肪变性的多血供肝癌的困难。(C)2004年爱思唯尔公司All rights reserved.
The purpose of this study was to investigate the efficacy of sensitivity encoding (SENSE) dynamic magnetic resonance imaging (MRI) with the dual (in-phase and opposed-phase) double arterial phase to detect hypervascular hepatocellular carcinomas (HCCs). MR images of the liver from 44 consecutive patients were obtained. Dynamic MRI with SENSE was performed six times (precontrast, early arterial, late arterial, 1 min, 3 min and 5 min after contrast injection) at 11 s per scan using the gradient recalled echo sequence (TR/TE/flip angle = 168/2.3 and 4.6/70). In-phase and opposed-phase images were obtained simultaneously each scan. For the quantitative analysis, the signal-to-noise ratio (S/N) of HCC and tumor-to-liver contrast-to-noise ratio (C/N) were analyzed for 55 HCCs. The mean S/N of HCCs on in-phase images showed significantly higher values than that on opposed-phase images regarding all phases (P < 0.001). In arterial phases. the mean tumor-to-liver C/N for in-phase images was significantly higher than that for opposed-phase images (P < 0.05). In portal and delayed-phase images. the mean tumor-to-liver C/N in opposed-phase images showed a negative value. In six HCCs with fatty metamorphosis, the mean tumor-to-liver C/N on arterial phase images approached zero in opposed-phase, while it showed a positive value in-phase. In dual double arterial phase dynamic MRI of the liver, in-phase images were superior to opposed-phase images for detecting early enhancement of hypervascular HCCs, while the latter were superior for detecting washout of contrast media from HCCs in the portal and delayed phase. The combination of both images overcomes the difficulty of diagnosing hypervascular HCCs with fatty metamorphosis. (C) 2004 Elsevier Inc. All rights reserved.