SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction
SAMDI Mass Spectrometry-Enabled High-Throughput Optimization of a Traceless Petasis Reaction
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DOI：
10.1021/acscombsci.5b00131
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发表时间：
2015-11-01
影响因子：
--
通讯作者：
Thomson, Regan J.
中科院分区：
文献类型：
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作者：
Diagne, Abdallah B.;Li, Shuheng;Thomson, Regan J.
描述了自组装单层/MALDI质谱（SAMDI）平台的开发，以实现无迹Petasis反应的高通量优化。在金上自组装的烷硫酸酯单层阵列上同时进行了1800多个独特的反应，以达到优化的条件，然后成功地转移到溶液阶段。该反应的实用性通过有效合成各种二取代和三取代烯得到验证。
Development of the self-assembled monolayer/MALDI mass spectrometry (SAMDI) platform to enable a high-throughput optimization of a traceless Petasis reaction is described. More than 1800 unique reactions were conducted simultaneously on an array of self-assembled monolayers of alkanethiolates on gold to arrive at optimized conditions, which were then successfully transferred to the solution phase. The utility of this reaction was validated by the efficient synthesis of a variety of di- and trisubstituted allenes.