Aging--RNA in development and disease.
Aging--RNA in development and disease.
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DOI：
10.1002/wrna.109
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发表时间：
2012-01
影响因子：
7.3
通讯作者：
Cookson, Mark R.
中科院分区：
文献类型：
--
作者：
Cookson, Mark R.
鉴于 RNA 几乎参与所有生物过程，因此多种 RNA 结合蛋白与衰老和不同年龄相关疾病相关也许并不奇怪。本卷的其他章节将讨论一些 RNA 发挥作用且与衰老相关的疾病的具体例子，例如癌症和炎症，因此在这里我将讨论 RNA 如何随衰老过程发生变化的一些一般方面。我还将讨论一些与年龄依赖性神经系统疾病相关的 RNA 结合蛋白的具体例子，因为它们提供了一个有趣的框架来研究终生突变如何导致迟发性疾病，尽管这些问题的答案仍然不是很清楚。
Given that RNA is involved in virtually all biological processes, it is perhaps not surprising that several RNA binding proteins are associated with aging and with different age related disorders. Other chapters in this volume will discuss some specific examples of diseases where RNA plays a role that are also associated with aging, such as cancer and inflammation, so here I will discuss some general aspects of how RNA changes with the aging process. I will also discuss some specific examples of RNA binding proteins that are associated with age-dependent neurological diseases as these provide an interesting framework to examine how lifetime mutations might lead to a late onset disease, although the answers to these questions are still not well understood.
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