The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma
The overexpression and predictive significance of MMP-12 in esophageal squamous cell carcinoma
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DOI：
10.1016/j.prp.2017.09.023
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发表时间：
2017-01-01
影响因子：
2.8
通讯作者：
Hao, Qiongyu
中科院分区：
文献类型：
--
作者：
Han, Fei;Zhang, Suxia;Hao, Qiongyu
基质金属蛋白酶（MMP）介导的细胞外基质降解是肿瘤侵袭和转移的主要因素。MMP-12作为金属弹性蛋白酶，其在肿瘤进展中的作用仍然是矛盾的。本研究旨在探讨MMP-12在食管鳞状细胞癌（ESCC）中的作用。我们分析了MMP-12的蛋白表达及其与临床病理参数的关系，以及生存分析。MMP-12在肿瘤细胞中的表达高于正常上皮细胞。MMP-12的高表达与食管鳞癌的分级、分期、淋巴结转移及生存期有关。考克斯多因素分析显示MMP-12是食管鳞癌的独立预后因素。我们的研究结果表明，MMP-12可能作为一个潜在的目标，为发展新的治疗食管鳞状细胞癌。
Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a major factor for tumor invasion and metastasis. MMP-12, as metalloelastase, its function in tumor progression remains contradictory. This study was undertaken to investigate the role of MMP-12 in esophageal squamous cell carcinoma (ESCC). We analyzed the protein expression of MMP-12 and its association with clinicopatholigical parameters, as well as survival analysis. MMP-12 was highly expressed in tumor cells comparing with normal epithelial cells. The high expression of MMP-12 was significantly correlated with tumor grade and stage, nodal metastasis and poor survival of ESCC. Cox multivariate analysis revealed that MMP-12 was an independent prognostic factor in ESCC. Our results suggest that MMP-12 might act as a potential target for the development of novel therapeutics of esophageal squamous cell carcinoma.