Epithelial resealing
Epithelial resealing
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DOI：
10.1387/ijdb.072308bg
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发表时间：
2009-01-01
影响因子：
0.7
通讯作者：
Jacinto, Antonio
中科院分区：
文献类型：
--
作者：
Garcia-Fernandez, Beatriz;Campos, Isabel;Jacinto, Antonio
上皮起着屏障的作用，保护活的有机体及其器官不受周围环境的影响。因此，尽管损伤、炎症和正常的细胞更新经常造成损害，但对于上皮组织来说，拥有强大的方法来保持其完整性是至关重要的。所有的上皮细胞都有一定的自我修复能力。然而，伤口的愈合过程在发育阶段和所涉及的组织类型之间有很大的不同。在这篇综述中，我们不会分析伤口愈合的所有方面；相反，我们将专注于几个简单的上皮组织具有的非常快速和有效地重新缝合微小不连续的能力，这一过程我们称为上皮重新封闭。我们将首先描述最初的实验，这些实验证明了修复胚胎伤口的钱包机制的存在，我们将把这一机制与解决正常发育过程中出现的上皮中断的胚胎形态发生运动进行比较。然后，我们将讨论在细胞培养系统和成人组织中发生上皮再密封的其他背景，这些背景表明，至少一些调节上皮再密封的机制可能是保守的，作用于几种类型的简单上皮，无论是在胚胎中还是在成人中，以及跨物种。
Epithelia have the essential role of acting as a barrier which protects living organisms and its organs from the surrounding milieu. Therefore, it is crucial for epithelial tissues to have robust ways of maintaining its integrity despite the frequent damage caused by injury, inflammation and normal cell turnover. All epithelia have some capacity to repair themselves. However,the wound-healing process differs dramatically between the developmental stage and the type of tissue involved. In this review, we will not analyse all aspects of wound healing; instead we will focus on the capacity which several simple epithelial tissues have to reseal small discontinuities very rapidly and efficiently, a process that we call epithelial resealing. We will start by describing the initial experiments which demonstrated the existence of a purse string mechanism to repair embryonic wounds and we will compare this mechanism with embryonic morphogenetic movements which resolve epithelial discontinuities that arise during the normal course of development. We will then discuss other contexts in which epithelia resealing occurs, both in cell culture systems and in adult tissues, and which suggest that at least some of the mechanisms that regulate epithelial resealing may be conserved, acting in several types of simple epithelia, both in embryos and in adults, and across species.