Early pregnancy lipid concentrations and spontaneous preterm birth
Early pregnancy lipid concentrations and spontaneous preterm birth
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DOI：
10.1016/j.ajog.2007.04.024
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发表时间：
2007-12-01
影响因子：
9.8
通讯作者：
Roberts, James M.
中科院分区：
文献类型：
--
作者：
Catov, Janet M.;Bodnar, Lisa M.;Roberts, James M.
目的：早产妇女患心血管疾病的风险可能增加，可能与血脂异常有关。研究设计：在一项针对自然早产妇女的嵌套病例对照研究中，评估了胆固醇、高密度脂蛋白、低密度脂蛋白和甘油三酯。对分娩34周(n=23)、34-37周(n=67)和37周(n=199)的孕妇进行了血脂浓度和妊娠变化以及早产风险的评估。结果：高胆固醇或高甘油三酯分别为34-和37周。分娩34周的超重妇女早期胆固醇和低密度脂蛋白浓度特别高；中度早产的瘦弱妇女甘油三酯升高。在分娩34周的妇女中，妊娠前半期的甘油三酯反应降低。结论：我们的结果表明自然早产妇女存在血脂异常。
OBJECTIVE: Women who deliver preterm infants may be at increased risk for cardiovascular disease, perhaps related to dyslipidemia.STUDY DESIGN: In a nested case control study of women with spontaneous preterm birth, cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were evaluated. Lipid concentrations and gestational changes, as well as risk for preterm birth, were evaluated in women who delivered < 34 (n = 23), >= 34-< 37 ( n = 67), and >= 37 weeks ( n = 199).RESULTS: High cholesterol or triglycerides = 34-< 37 weeks, respectively. Overweight women who delivered < 34 weeks had particularly elevated early pregnancy concentrations of cholesterol and low-density lipoprotein; lean women with moderate preterm birth had elevated triglycerides. There was a reduced triglyceride response in the first half of pregnancy among women who delivered < 34 weeks.CONCLUSION: Our results indicate the presence of dyslipidemia in women with spontaneous preterm birth.