Rapid changes in rotaviral genotypes in Ecuador.
Rapid changes in rotaviral genotypes in Ecuador.
复制标题
厄瓜多尔轮状病毒基因型的快速变化。
DOI：
10.1002/jmv.21632
复制
发表时间：
2009
影响因子：
12.7
通讯作者：
Eisenberg,JosephNS
中科院分区：
文献类型：
--
作者：
Hasing,MariaEloisa;Trueba,Gabriel;Baquero,MariaInes;Ponce,Karina;Cevallos,William;Solberg,OwenD;Eisenberg,JosephNS
以前的研究表明，新出现的G9P[8]基因是2005年厄瓜多尔最流行的轮状病毒基因。本研究通过在最初报告的2005年数据基础上增加年份(2006年至2008年初)，对厄瓜多尔境内两个地点轮状病毒基因类型的分布进行了时间分析。数据是在农村(厄瓜多尔北部沿海)和城市(基多)地区收集的。在农村地区，2003年8月至2008年3月期间收集了病例(有腹泻症状)和对照(无腹泻病例)的社区样本，共采集了3,300份粪便样本(876例和2,424名对照)。免疫层析检测轮状病毒阳性2 6 0例(19 6例)，对照1 96例。在基多，从表现为腹泻的儿童身上收集了59份粪便样本，并被诊断为轮状病毒。对2005至2007年间收集的样本进行的RT-PCR分析表明，在农村和城市环境中，G9被G1和G2取代。在此期间，在农村社区，G9从79%下降到9%，而G2从0%增加到43%；在基多市区，G9从79%下降到37%，G2从3%增加到57%。G9迅速被G1和G2取代，加强了监测的必要性，以便为疫苗接种计划提供信息。J.Med.维罗尔。81：2109-2113,2009。©2009威利-利斯，Inc.
Previous studies suggest that the emerging G9P[8] genotype was the most prevalent rotavirus genotype in Ecuador during 2005. This present study provides a temporal analysis of the distribution of rotavirus genotypes in two locations within Ecuador by adding additional years (2006 — early 2008) to the originally reported 2005 data. Data were collected in a rural (northern coastal Ecuador) and urban (Quito) area. In the rural area, a community sample of cases (those presenting diarrhea) and controls (those not presenting diarrhea) were collected between August 2003 and March 2008 resulting in a total of 3,300 stool samples (876 cases and 2,424 controls). Of these samples, 260 were positive for rotavirus by an immunochromatographic test (196 cases and 64 controls). In Quito, 59 fecal samples were collected from children presenting diarrhea and diagnosed with rotavirus. An RT‐PCR analysis of samples collected between 2005 and 2007 suggested that G9 was replaced by G1 and G2 in the rural and urban settings. During this period G9 decreased from 79% to 9% while G2 increased from 0% to 43% in the rural communities, and G9 decreased from 79% to 37% while G2 increased from 3% to 57% in the urban area of Quito. This rapid replacement of G9 by G1 and G2 reinforces the necessity of surveillance to inform vaccination programs. J. Med. Virol. 81:2109–2113, 2009. © 2009 Wiley‐Liss, Inc.