The Role of Histone Protein Acetylation in Regulating Endothelial Function.
The Role of Histone Protein Acetylation in Regulating Endothelial Function.
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DOI：
10.3389/fcell.2021.672447
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发表时间：
2021
影响因子：
5.5
通讯作者：
Miao QR
中科院分区：
文献类型：
--
作者：
Fang Z;Wang X;Sun X;Hu W;Miao QR
内皮细胞（Endothelial cell， EC）是各种血管的最内层细胞，它不仅是血管屏障的缔造者，而且在生理过程中发挥着多种功能。积极控制血管张力和水、溶质、大分子的外渗；调节循环免疫细胞以及血小板和白细胞的募集/粘附和激活。此外，EC还紧密保持凝血/纤溶平衡，在血管生成中起重要作用。因此，内皮功能障碍与许多疾病的发病机制有关。越来越多的证据表明，组蛋白乙酰化作为一种表观遗传标记，在不同条件下在内皮细胞中发生改变，组蛋白不同赖氨酸位点乙酰化状态的改变在内皮功能障碍中起关键作用，参与高血糖、高血压、炎症疾病、癌症等。在这篇综述中，我们强调了组蛋白乙酰化在调节内皮功能中的重要性，并讨论了组蛋白乙酰化在不同疾病相关病理生理过程中在内皮细胞中蛋白质编码基因转录单元中的作用。由于组蛋白乙酰化变化是保守的和可逆的，因此了解组蛋白乙酰化在内皮功能调节中的作用可以为开发预防或治疗内皮功能障碍相关疾病的表观遗传干预提供见解。
Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not only a barrier composer but also performing multiple functions in physiological processes. It actively controls the vascular tone and the extravasation of water, solutes, and macromolecules; modulates circulating immune cells as well as platelet and leukocyte recruitment/adhesion and activation. In addition, EC also tightly keeps coagulation/fibrinolysis balance and plays a major role in angiogenesis. Therefore, endothelial dysfunction contributes to the pathogenesis of many diseases. Growing pieces of evidence suggest that histone protein acetylation, an epigenetic mark, is altered in ECs under different conditions, and the acetylation status change at different lysine sites on histone protein plays a key role in endothelial dysfunction and involved in hyperglycemia, hypertension, inflammatory disease, cancer and so on. In this review, we highlight the importance of histone acetylation in regulating endothelial functions and discuss the roles of histone acetylation across the transcriptional unit of protein-coding genes in ECs under different disease-related pathophysiological processes. Since histone acetylation changes are conserved and reversible, the knowledge of histone acetylation in endothelial function regulation could provide insights to develop epigenetic interventions in preventing or treating endothelial dysfunction-related diseases.
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