Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation
Dynamic focus optical coherence tomography: feasibility for improved basal cell carcinoma investigation
复制标题
动态聚焦光学相干断层扫描：改进基底细胞癌研究的可行性
DOI：
10.1117/12.912081
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
A. Podoleanu
中科院分区：
文献类型：
--
作者：
M. R. Nasiri;A. Aber;S. A. Hojjatoleslami;M. Sira;J. Schofield;Carole A. Jones;A. Podoleanu
基底细胞癌（BCC）是最常见的皮肤癌。为了提高诊断准确性，人们寻求其他非侵入性的初步诊断方法。我们为这项研究实施了 En-Face 光学相干断层扫描 (OCT)，其中集成了动态焦点。采用动态聚焦方案，相干门与由共焦界面光学器件确定的共焦门峰值同步移动。然后，横向分辨率在整个深度范围内保持不变，并且从所有深度返回增强的信号。基底细胞癌标本取自患者的眼睑。通过 DF-OCT 成像对样本进行分析。我们寻找通过 OCT 可视化的显着特征，并将这些发现与组织学切片中呈现的特征进行比较。
Basal cell carcinoma (BCC) is the most common form of skin cancer. To improve the diagnostic accuracy, additional non-invasive methods of making a preliminary diagnosis have been sought. We have implemented an En-Face optical coherence tomography (OCT) for this study in which the dynamic focus was integrated into it. With the dynamic focus scheme, the coherence gate moves synchronously with the peak of confocal gate determined by the confocal interface optics. The transversal resolution is then conserved throughout the depth range and an enhanced signal is returned from all depths. The Basal Cell Carcinoma specimens were obtained from the eyelid a patient. The specimens under went analysis by DF-OCT imaging. We searched for remarkable features that were visualized by OCT and compared these findings with features presented in the histology slices.