Quantification of photoreceptor layer thickness in normal eyes using optical coherence tomography
Quantification of photoreceptor layer thickness in normal eyes using optical coherence tomography
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DOI：
10.1097/00006982-200607000-00011
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发表时间：
2006-07-01
影响因子：
3.3
通讯作者：
Fujimoto, James G.
中科院分区：
文献类型：
--
作者：
Chan, Annie;Duker, Jay S.;Fujimoto, James G.
目的：为了证明使用从最新的市售光学相干断层扫描（OCT）系统（StratusOCT; Carl Zeiss Meditec，Inc.，都柏林，CA）和高分辨率OCT（UHR-OCT）原型。方法：37名健康受试者的37只眼睛使用StratusOCT和UHR-OCT进行了完整的眼科检查。使用分割算法识别和测量ORC。结果：对于StratusOCT，平均加权ORC厚度+/- SD为91.1 +/- 7.9 μ m，平均加权总视网膜厚度+/- SD确定为258.9 +/- 10.1 μ m。对于UHR-OCT，平均加权ORC厚度SD为96.4 +/- 6.3 μ m，平均加权总视网膜厚度+/- SD确定为263.4 +/- 9.2 μ m。UHR-OCT images.Conclusions的算法失败率较高：感光层厚度可以通过使用黄斑分割算法测量OCT图像上的ORC来计算。ORC值可以作为一个有用的客观参数，在确定各种疾病中靶向感光层的各种治疗方式的疗效。
Objective: To demonstrate the ability to segment and analyze individual intraretinal layers, including the outer retinal complex (ORC; outer nuclear layer and inner and outer segments of the photoreceptor cells), in healthy eyes using images acquired from the latest commercially available optical coherence tomography (OCT) system (StratusOCT; Carl Zeiss Meditec, Inc., Dublin, CA) and from the ultrahigh resolution OCT (UHR-OCT) prototype.Methods: Thirty-seven eyes from 37 healthy subjects underwent complete ophthalmologic examination using StratusOCT and UHR-OCT. ORC was identified and measured using a segmentation algorithm.Results: For StratusOCT, mean weighted ORC thickness +/- SD was 91.1 +/- 7.9 mu m, and mean weighted total retinal thickness +/- SD was determined to be 258.9 +/- 10.1 mu m. For UHR-OCT, mean weighted ORC thickness SD was 96.4 +/- 6.3 mu m, and mean weighted total retinal thickness +/- SD was determined to be 263.4 +/- 9.2 mu m. There was a higher rate of algorithm failure with UHR-OCT images.Conclusions: Photoreceptor layer thickness can be calculated by measuring ORC on OCT images using a macular segmentation algorithm. ORC values may serve as a useful objective parameter in determining the efficacy of various therapeutic modalities that target the photoreceptor layer in various diseases.