The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort.
The Association Between Risk Factors for Metabolic Syndrome and Meibomian Gland Disease in a Dry Eye Cohort.
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DOI：
10.2147/opth.s322461
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Robertson DM
中科院分区：
文献类型：
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作者：
Mussi N;Haque W;Robertson DM
代谢综合征的风险因素包括腹部肥胖、胰岛素抵抗、高血压、高甘油三酯和/或低高密度脂蛋白胆固醇以及高血糖症。代谢综合征的危险因素与干眼症有关;然而，它们与睑板腺疾病（MGD）（干眼症的一种亚型）的关系尚不清楚。在本研究中，我们调查了有和没有MGD的干眼队列中代谢综合征的危险因素。这项回顾性病例对照研究评价了一家主要城市门诊医疗中心的电子病历，以识别已知诊断为干眼病的患者，包括有无MGD。男性和女性在年龄、吸烟状况、人种、种族和体重指数（BMI）方面相匹配。分析患者人口统计学、人体测量、病史、临床结果和血清学。MGD的诊断基于病历中记录的临床体征。在干眼队列中，MGD与BMI、吸烟、2型糖尿病、高血压或高脂血症无关。MGD与男性和年龄增加有关。虽然年龄的增加与低密度脂蛋白胆固醇和非高密度脂蛋白胆固醇的降低呈弱相关，但血脂水平与MGD无关。重要的是，我们发现，与非MGD干眼受试者相比，代谢综合征的风险因素与MGD的增加并不特别相关。虽然代谢综合征的风险因素与干眼病相关，但它们可能反映了慢性全身性低度炎症状态，对泪腺和睑板腺的功能产生负面影响。
Risk factors for metabolic syndrome include abdominal obesity, insulin resistance, hypertension, high triglycerides and/or low high-density lipoprotein cholesterol, and hyperglycemia. Risk factors for metabolic syndrome have been associated with dry eye disease; however, their association with meibomian gland disease (MGD), a subtype of dry eye, is unclear. In the present study, we investigated risk factors for metabolic syndrome in a dry eye cohort with and without MGD. This retrospective case-control study evaluated electronic medical records at a major urban outpatient medical center to identify patients with a known diagnosis of dry eye disease with and without MGD. Males and females were matched for age, smoking status, race, ethnicity, and body mass index (BMI). Patient demographics, anthropometric measurements, medical history, clinical findings, and serologies were analyzed. A diagnosis of MGD was based on clinical signs noted in the medical record. MGD was not associated with BMI, smoking, type 2 diabetes mellitus, hypertension or hyperlipidemia in this dry eye cohort. MGD was associated with male sex and increasing age. While increasing age was weakly correlated with decreased low density lipoprotein cholesterol and non-high density lipoprotein cholesterol, serum lipid levels were not associated with MGD. Importantly, we found that risk factors for metabolic syndrome are not specifically associated with an increase in MGD when compared to non-MGD dry eye subjects. While risk factors for metabolic syndrome are associated with dry eye disease, they likely reflect a chronic systemic state of low-grade inflammation that negatively impacts the function of both lacrimal and meibomian glands.