Stress, hippocampal plasticity, and spatial learning
Stress, hippocampal plasticity, and spatial learning
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DOI：
10.1002/syn.1040
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发表时间：
2001-06-01
期刊：
影响因子：
2.3
通讯作者：
Garcia, R
中科院分区：
文献类型：
--
作者：
Garcia, R
在过去的二十年中，许多研究已经进行，试图将海马突触传递的长时程增强（LTP）机制与海马中空间记忆形成所需的机制相关联。由于应激事件阻断了海马LTP的诱导，因此有人认为应激后空间学习的缺陷可能与海马LTP样现象的抑制有关。在这里，我回顾这些研究，并讨论他们在新兴的观点，即压力可能会引起变化的阈值突触可塑性都LTP诱导和空间记忆形成所必需的。这种现象被称为变形性，可能涉及糖皮质激素对钙稳态的调节。Synapse 40：180-183，2001. (C)2001 Wiley-Liss，Inc.
During the last two decades numerous studies have been conducted in an attempt to correlate the mechanisms of long-term potentiation (LTP) of hippocampal synaptic transmission with those required for spatial memory formation in the hippocampus. Because stressful events block the induction of hippocampal LTP, it has been suggested that deficits in spatial learning following stress may be related to suppression of LTP-like phenomena in the hippocampus. Here I review these studies and discuss them in light of the emerging view that stress may induce changes in thresholds for synaptic plasticity necessary for both LTP induction and spatial memory formation. This phenomenon, known as metaplasticity, may involve a glucocorticoid modulation of calcium homeostasis. Synapse 40:180-183, 2001. (C) 2001 Wiley-Liss, Inc.