Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid.
Suppression of human macrophage interleukin-6 by a nonpsychoactive cannabinoid acid.
复制标题
非精神活性大麻酸对人巨噬细胞白细胞介素 6 的抑制。
DOI：
10.1007/s00296-007-0489-0
复制
发表时间：
2008
影响因子：
4
通讯作者：
Zurier,RobertB
中科院分区：
文献类型：
--
作者：
Parker,Jennifer;Atez,Francisco;Rossetti,RonaldG;Skulas,Ann;Patel,Rakesh;Zurier,RobertB
白细胞介素-6（IL-6）是一种多功能细胞因子，在多种疾病中促进炎症和组织损伤。因此，抑制IL-6的产生可能是治疗类风湿性关节炎（RA）和系统性红斑狼疮（SLE）等疾病患者的有效策略。一种合成的非精神活性大麻素，阿佳酸（AjA），可预防实验性关节炎的关节损伤。本文提供的实验结果表明，在体外向人单核细胞衍生的巨噬细胞中加入AjA（3-30 μM）可降低IL-6 mRNA的稳态水平和随后LPS刺激细胞的IL-6分泌。虽然AjA结合并激活PPARγ，但其抗IL-6作用是不依赖于PPARγ的。这些研究提供的证据支持AjA可能被证明是一种有效、安全的抗肿瘤药物的观点。
Interleukin-6 (IL-6) is a multifunctional cytokine which contributes to inflammation and tissue injury in several diseases. Thus, inhibition of IL-6 production may be a useful strategy for treatment of patients with diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). A synthetic nonpsychoactive cannabinoid, ajulemic acid (AjA), prevents joint damage in experimental arthritis. Results of experiments presented here indicate that addition of AjA (3–30 μM) to human monocyte derived macrophages in vitro reduces steady state levels of IL-6 mRNA and the subsequent secretion of IL-6 from LPS stimulated cells. Although AjA binds to and activates PPARγ, its anti IL-6 effects are PPARγ independent. These studies provide evidence to support the view that AjA may prove to be an effective, safe antiinflammatory agent.