Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
Human lysosomal acid lipase inhibitor lalistat impairs Mycobacterium tuberculosis growth by targeting bacterial hydrolases
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DOI：
10.1039/c6md00231e
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发表时间：
2016-01-01
期刊：
影响因子：
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通讯作者：
Sieber, S. A.
中科院分区：
文献类型：
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作者：
Lehmann, J.;Vomacka, J.;Sieber, S. A.
Lalistat抑制结核分枝杆菌在细菌培养和感染的巨噬细胞中的生长。通过定量蛋白质组学进行靶标鉴定，发现了包括脂肪酶家族成员在内的20个水解性蛋白质簇。脂肪酶对结核分枝杆菌脂肪酸的产生和能量储存是必不可少的，因此是很有前途的抗生素靶标。
Lalistat inhibits growth of Mycobacterium tuberculosis in bacterial culture as well as in infected macrophages. Target identification by quantitative proteomics revealed a cluster of 20 hydrolytic proteins including members of the lipase family. Lipases are essential for M. tuberculosis fatty acid production and energy storage thus representing promising antibiotic targets.