INTRACEREBRAL RECORDINGS OF SLOW POTENTIALS IN A CONTINGENT NEGATIVE-VARIATION PARADIGM - AN EXPLORATION IN EPILEPTIC PATIENTS
INTRACEREBRAL RECORDINGS OF SLOW POTENTIALS IN A CONTINGENT NEGATIVE-VARIATION PARADIGM - AN EXPLORATION IN EPILEPTIC PATIENTS
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DOI：
10.1016/0013-4694(95)00117-h
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发表时间：
1995-10-01
期刊：
影响因子：
--
通讯作者：
REKTOR, I
中科院分区：
文献类型：
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作者：
LAMARCHE, M;LOUVEL, J;REKTOR, I
在探索癫痫患者与脑内多导联电极，我们应用了一个预先警告的反应时间任务与两个连续的声音刺激，一个范例，是已知的，引起一个偶然的负变（CNV）。第二个是命令性声音刺激，随后是手或脚的运动。对11名患有耐药性部分癫痫的患者进行了测试。在两个刺激之间的时间期间发展的慢电位通常不是典型的CNV（有时包括具有不同极性的多个连续分量）。这种“类CNV”电位来自两个主要的皮质区：一个是中央区，包括运动前区、运动区、辅助运动区、中央后区和扣带区;另一个是颞区，主要包括听觉皮质及其附近区域，在某些情况下还包括杏仁核。这种有限的定位与头皮上更广泛的CNV形成对比。从两个半球获得脑内CNV样事件，独立于所进行运动的一侧。在一些患者中，准备电位（RP）也被记录用于比较，并显示出更有限的范围，只存在于对侧运动皮层和双侧的补充运动区。我们的数据表明，CNV的最后一部分不能仅仅与RP相鉴别。
While exploring epileptic patients with intracerebral multilead electrodes, we applied a forewarned reaction time task with two successive sound stimuli, a paradigm that is known to elicit a contingent negative variation (CNV). The second, imperative sound stimulus was followed by a hand or a foot movement. Eleven patients suffering drug-resistant partial epilepsies were tested. The slow potentials developing during the time between the two stimuli were usually not typical CNVs (sometimes comprising multiple successive components with distinct polarities). Such ''CNV-like'' potentials were obtained from two main cortical zones: a central one including premotor, motor, supplementary motor, postcentral and cingulate areas; and a temporal zone, mainly including the auditory cortex and its vicinity, and in some cases the amygdala. This restricted localization contrasted with the broader extent of the CNVs on the scalp. Intracerebral CNV-like events were obtained from both hemispheres, independent of the side of the performed movement. In some patients, readiness potentials (RPs) were also recorded for comparison and displayed a more restricted extent, being present only on the contralateral motor cortex and bilaterally in the supplementary motor areas. Our data suggest that the last part of the CNV cannot just be identified with the RP.