Cell motility: the integrating role of the plasma membrane.
Cell motility: the integrating role of the plasma membrane.
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DOI：
10.1007/s00249-011-0741-0
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发表时间：
2011-09
影响因子：
2
通讯作者：
Keren, Kinneret
中科院分区：
文献类型：
--
作者：
Keren, Kinneret
质膜在运动过程中起着至关重要的作用。它定义了分离细胞内和细胞外环境的边界，并介导运动细胞与其环境之间的相互作用。此外，膜作为一个动态平台，用于定位各种成分，这些成分积极参与运动过程的各个方面，包括力的产生、粘附、信号传导和调节。内膜和质膜之间的膜转运，特别是极化膜转运，促进质膜的连续重组，并被认为参与维持极性和某些运动细胞类型中必需组分的再循环。除了其生化组成，质膜的机械特性，特别是膜张力在细胞运动中具有核心重要性;膜张力影响所有涉及膜变形的过程的速率，包括边缘延伸、内吞和胞吐。最重要的是，膜的力学特性与其生化组成紧密交织在一起;膜张力和局部曲率很大程度上取决于膜的生化组成和发生的生化反应;同时，曲率和张力影响组分的定位和反应速率。本文综述了这种动态的相互作用和反馈之间的生物化学和生物物理特性的膜和它们对细胞运动的影响。新的见解，这些将是至关重要的理解运动过程。
The plasma membrane is of central importance in the motility process. It defines the boundary separating the intracellular and extracellular environments, and mediates the interactions between a motile cell and its environment. Furthermore, the membrane serves as a dynamic platform for localization of various components which actively participate in all aspects of the motility process, including force generation, adhesion, signaling, and regulation. Membrane transport between internal membranes and the plasma membrane, and in particular polarized membrane transport, facilitates continuous reorganization of the plasma membrane and is thought to be involved in maintaining polarity and recycling of essential components in some motile cell types. Beyond its biochemical composition, the mechanical characteristics of the plasma membrane and, in particular, membrane tension are of central importance in cell motility; membrane tension affects the rates of all the processes which involve membrane deformation including edge extension, endocytosis, and exocytosis. Most importantly, the mechanical characteristics of the membrane and its biochemical composition are tightly intertwined; membrane tension and local curvature are largely determined by the biochemical composition of the membrane and the biochemical reactions taking place; at the same time, curvature and tension affect the localization of components and reaction rates. This review focuses on this dynamic interplay and the feedbacks between the biochemical and biophysical characteristics of the membrane and their effects on cell movement. New insight on these will be crucial for understanding the motility process.
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作者：
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