The metabolism of benomyl fungicide in mammals.
The metabolism of benomyl fungicide in mammals.
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苯菌灵杀菌剂在哺乳动物中的代谢。
DOI：
10.3109/00498257309151529
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发表时间：
1973
期刊：
影响因子：
--
通讯作者：
P. Douch
中科院分区：
文献类型：
--
作者：
P. Douch
摘要1.已在小鼠、兔和绵羊以及这些物种的酶制剂中研究了苯诺明（1-（丁基氨基甲酰基）-苯并咪唑-2-基氨基甲酸甲酯）的代谢。2.在所有三个物种中，两种代谢产物通过羟基化形成，两种通过酯水解形成。羟基化代谢产物以硫酸盐和葡糖苷酸结合物的形式从所有种属中排泄。未检测到与乙酸的结合物。每种属约20%的给药剂量以羟基化代谢物结合物的形式消除。SKF 525 A在体外可抑制羟基化代谢物的形成.在所有三个种属的肝酶制剂中，2-氨基苯并咪唑被羟基化，得到5-羟基-2-氨基苯并咪唑。
Abstract1. The metabolism of Benomyl (methyl 1-(butylcarbamoyl)-benzimidazol-2-ylcarbamate) has been studied in mice, rabbits and sheep, and in enzyme preparations from these species.2. In all three species two metabolites were formed by hydroxylation, and two by ester hydrolysis. The hydroxylated metabolites were excreted from all species as the sulphate and glucuronide conjugates. Conjugates with acetic acid were not detected.3. About 20% of the dose administered to each species was eliminated as conjugates of hydroxylated metabolites. Formation of hydroxylated metabolites was inhibited by SKF 525A in vitro.4. In liver enzyme preparations from all three species, 2-amino-benzimidazole was hydroxylated to give 5-hydroxy-2-aminobenzimidazole.