POSTSYNAPTIC CONTROL OF LUMBAR MOTO-NEURON EXCITABILITY DURING ACTIVE SLEEP IN THE CHRONIC CAT
POSTSYNAPTIC CONTROL OF LUMBAR MOTO-NEURON EXCITABILITY DURING ACTIVE SLEEP IN THE CHRONIC CAT
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DOI：
10.1016/0006-8993(81)90836-2
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
CHASE, MH
中科院分区：
文献类型：
--
作者：
MORALES, F;CHASE, MH
在慢性、未麻醉、未用药的正常呼吸猫中进行了睡眠和清醒期间腰部运动神经元兴奋性的相关细胞内和细胞外研究。实验旨在揭示哺乳动物主动睡眠期间肌张力低下在多大程度上依赖于体细胞运动神经元的突触后抑制。研究了逆向场电位、逆向和顺向尖峰、EPSP（兴奋性突触后电位）膜输入电阻和流变电流的变化。当安静清醒与安静睡眠进行比较时，运动神经元兴奋性没有发生变化。在主动睡眠期间，由于突触后抑制，兴奋性下降是预先设定的。兴奋性的进一步阶段性降低（也是由于突触后抑制）在主动睡眠期间与快速眼球运动一起发生。
A correlated intracellular and extracellular study of lumbar motoneuron excitability during sleep and wakefulness was performed in the chronic, unanesthetized, undrugged normally respiring cat. Experiments were designed to reveal the extent to which hypotonia during active sleep in mammals is dependent on postsynaptic inhibition of somatic motoneurons. Variations in the antidromic field potential, antidromic and orthodromic spike, EPSP [excitatory postsynaptic potential] membrane input resistace and rheobasic current were studied. No change in motoneuron excitability occurred when quiet wakefulness was compared to quiet sleep. A decrease in excitability was preset, due to postsynaptic inhibition, during active sleep. Further phasic decreases in excitabiity, also due to postsynaptic ihibition, occurred during active sleep in conjunction with clusters of rapid eye movement.