Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies
Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies
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DOI：
10.1136/gut.2008.166710
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发表时间：
2009-10-01
期刊：
影响因子：
24.5
通讯作者：
Tsugane, S.
中科院分区：
文献类型：
--
作者：
Inoue, M.;Sasazuki, S.;Tsugane, S.
背景：之前的实验研究表明绿茶有许多可能的抗癌机制，但关于绿茶消费对胃癌风险影响的流行病学证据是相互矛盾的。目的：检查绿茶消费与胃癌之间的关联。方法：我们分析了六项队列研究的原始数据，这些研究使用经过验证的基线问卷测量绿茶消费量。计算各个研究中的风险比 (HR)，调整一组常见变量，并使用随机效应模型进行组合。结果：在对 219080 名受试者进行 2285968 人年的随访期间，发现了 3577 例胃癌。与饮酒量 = 5 杯/天的人相比（多变量调整汇总 HR = 0.79，95% 置信区间 (CI) = 0.65 至 0.96）。这种下降对于远端亚位点也很显着（HR = 0.70，95% CI = 0.50 至 0.96）。相比之下，男性和女性均未发现与近端胃癌的相关性。结论：绿茶可能会降低女性患远端胃癌的风险。
Background: Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting.Objective: To examine the association between green tea consumption and gastric cancer.Methods: We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model.Results: During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking = 5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women.Conclusions: Green tea may decrease the risk of distal gastric cancer in women.