Genomic signatures of mitonuclear coevolution across populations of Tigriopus californicus
Genomic signatures of mitonuclear coevolution across populations of Tigriopus californicus
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DOI：
10.1038/s41559-018-0588-1
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发表时间：
2018-08-01
影响因子：
16.8
通讯作者：
Burton, Ronald S.
中科院分区：
文献类型：
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作者：
Barreto, Felipe S.;Watson, Eric T.;Burton, Ronald S.
桡足类Tigriopus californicus表现出广泛的种群分化，并正在成为理解异域分化和物种形成早期阶段的模型。在这里，我们报告了一个人群的高质量参考基因组（类似于12个支架上的190兆碱基，类似于15，500个蛋白质编码基因）。与其他节肢动物的比较显示，2,526个基因被认为是T。加利福尼亚州，参与离子转运和受体活性的基因明显增生。除了参考人群之外，我们还报告了另外七个人群的基因组重新测序，这些人群跨越了生殖隔离的连续体。种群表现出极端的线粒体DNA分歧，具有比其他类群中观察到的更高水平的氨基酸分化。在整个核基因组中，我们发现预测与线粒体DNA及其在多个途径中编码的蛋白质和RNA相互作用的基因中的蛋白质进化速率升高和正选择。总之，这些结果支持的假设，线粒体的快速进化驱动补偿核进化内孤立的人群，从而提供了一个潜在的重要机制，造成内在的生殖隔离。
The copepod Tigriopus californicus shows extensive population divergence and is becoming a model for understanding allopatric differentiation and the early stages of speciation. Here, we report a high-quality reference genome for one population (similar to 190 megabases across 12 scaffolds, and similar to 15,500 protein-coding genes). Comparison with other arthropods reveals 2,526 genes presumed to be specific to T. californicus, with an apparent proliferation of genes involved in ion transport and receptor activity. Beyond the reference population, we report re-sequenced genomes of seven additional populations, spanning the continuum of reproductive isolation. Populations show extreme mitochondrial DNA divergence, with higher levels of amino acid differentiation than observed in other taxa. Across the nuclear genome, we find elevated protein evolutionary rates and positive selection in genes predicted to interact with mitochondrial DNA and the proteins and RNA it encodes in multiple pathways. Together, these results support the hypothesis that rapid mitochondrial evolution drives compensatory nuclear evolution within isolated populations, thereby providing a potentially important mechanism for causing intrinsic reproductive isolation.