Evaluating Breast Cancer Risk under Exposureto Environmental Estrogen-Like Chemicals
Evaluating Breast Cancer Risk under Exposureto Environmental Estrogen-Like Chemicals
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DOI：
10.15244/pjoes/64282
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发表时间：
2016-11
影响因子：
1.8
通讯作者：
Yuanfang He;Xiaoling Wang;Kusheng Wu
中科院分区：
文献类型：
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作者：
Yuanfang He;Xiaoling Wang;Kusheng Wu
乳腺癌是世界上最常见的女性癌症，近几十年来发病率显著上升。许多具有雌激素活性的环境化合物，称为环境雌激素（environmental estrogen, EEs），尤其是持久性有机污染物，可能在乳腺癌的发生发展甚至治疗和预后中发挥重要作用。电子电气化合物，包括双酚A、壬基酚、邻苯二甲酸酯、全氟辛烷磺酸、多溴联苯醚、二恶英和多氯联苯，是工业制造的产物，在人类环境中无处不在。随着环境污染的加剧，这些化合物在各种环境基质中都有残留，特别是在工业发达国家。人类经常通过各种途径接触到它们，包括身体接触、吸入、饮食、家用产品、灰尘和化妆品。在许多类型的人类标本中都发现了它们。它们在环境基质和人类中的持久性引起了全球的关注，因为它们对公众健康的影响，特别是乳腺癌的发生。本文就这7种常见的雌激素类化学物质在工业污染物中的研究进展进行综述，以期为暴露于环境中的雌激素样化学物质导致乳腺癌的风险提供证据，并为乳腺癌的预防和控制提供线索。
Breast cancer is the most prevalent cancer among women in the world, with a notable increasing prevalence in recent decades. Many environmental compounds with estrogenic activity, called environmental estrogens (EEs), which are especially persistent organic pollutants, may play important roles in the occurrence and development of breast cancer and even treatment and prognosis. EE compounds, including bisphenol A, nonylphenol, phthalates, perfluorooctane sulfonate, polybrominated diphenyl ethers, dioxins, and polychlorinated biphenyls, result from industrial manufacturing and exist ubiquitously in the human environment. With the aggravation of environmental pollution, these compounds are residual in all kinds of environmental matrices – especially in industrialized countries. Humans are frequently exposed to them through various pathways, including body contact, inhalation, diet, household products, dust, and cosmetics. They have been detected in many types of human specimens. Their persistence in environmental matrices and humans has aroused global attention because of their effect on public health, especially the occurrence of breast cancer. In this review, we focus on recent research of these seven familiar EEs in industrial pollutants to provide insight into the evidence for risk of breast cancer with exposure to environmental estrogen-like chemicals and to provide clues for prevention and control of breast cancer.