Revisiting yeast trehalose metabolism
Revisiting yeast trehalose metabolism
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DOI：
10.1007/s00294-014-0450-1
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发表时间：
2015-08-01
期刊：
影响因子：
2.5
通讯作者：
Magalhaes, Rayne
中科院分区：
文献类型：
--
作者：
Eleutherio, Elis;Panek, Anita;Magalhaes, Rayne
海藻糖在酵母细胞中的功能研究经历了一个漫长的过程，从简单的能量储存碳水化合物，到膜和蛋白质的稳定剂和保护剂，再到抗氧自由基损伤的安全阀，最后发展到糖酵解途径的调节剂，此外，海藻糖的生物合成也被认为是抗多种病原体药物的靶点。由于这一途径在哺乳动物细胞中完全不存在，并利用高度特异性的酶，海藻糖代谢可能是开发新疗法的一个有趣的目标。在这篇综述中，我们想解决一些最近的点研究有关海藻糖代谢的酿酒酵母，主要集中在这个简单的二糖保护免受压力的机制和参与其合成和分解的酶。我们相信这些概念对于医学和生物技术应用非常重要。
Establishing the function of trehalose in yeast cells has led us, over the years, through a long path-from simple energy storage carbohydrate, then a stabilizer and protector of membranes and proteins, through a safety valve against damage caused by oxygen radicals, up to regulator of the glycolytic path. In addition, trehalose biosynthesis has been proposed as a target for novel drugs against several pathogens. Since this pathway is entirely absent in mammalian cells and makes use of highly specific enzymes, trehalose metabolism might be an interesting target for the development of novel therapies. In this review, we want to address some recent points investigated about trehalose metabolism in Saccharomyces cerevisiae, focusing mainly on the mechanism by which this simple disaccharide protects against stress and on the enzymes involved in its synthesis and breakdown. We believe that these concepts are of great importance for medical and biotechnological applications.