Simulated blood transport of low density lipoproteins in a three-dimensional and permeable T-junction.
Simulated blood transport of low density lipoproteins in a three-dimensional and permeable T-junction.
复制标题
模拟低密度脂蛋白在三维可渗透 T 形接头中的血液运输。
DOI：
10.1097/01.mat.0000160579.11018.ae
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Collins,WilliamE
中科院分区：
文献类型：
--
作者：
Shibeshi,ShewaferawS;Everett,Joseph;Venable,DemetriusD;Collins,WilliamE
以往的研究表明，心血管系统和组织中大分子的血流和运输对于了解动脉疾病的发生和发展、动脉移植的有效实施以及设计有效的药物传递机制至关重要。在本研究中，我们使用计算流体动力学来模拟低密度脂蛋白（LDL）在三维可渗透T结中的血流和运输。Navier-Stokes方程、Darcy定律和对流扩散方程是用来模拟系统流动和输运现象的数学模型。在数值模型中实现有限体积法，我们使用了计算流体力学软件Fluent 6.1。模拟结果表明，在生理流动条件下，交界处管腔表面的LDL浓度较高。在从管腔表面进入动脉1mm深度处，LDL浓度约为管腔浓度的40%，在2mm深度处，LDL浓度降至20%。最终，浓度进一步下降，在外壁边界处达到零。
Previous studies indicate that blood flow and transport of macromolecules in the cardiovascular system and tissues are essential to understand the genesis and progression of arterial diseases and for the effective implementation of arterial grafts, as well as to devise efficient drug delivery mechanisms. In the present study, we use computational fluid dynamics to simulate the blood flow and transport of low-density lipoproteins (LDL) in a three-dimensional and permeable T junction. The Navier-Stokes equation, Darcy’s Law, and the advective diffusion equations are the mathematical models used to simulate the flow and transport phenomena of the system. In the numeric model to implement the finite volume method, we used the computational fluid dynamics software Fluent 6.1. The simulation shows higher LDL concentration in the luminal surface at the junction under physiologic flow conditions. At 1 mm depth into the artery from the luminal surface, the LDL concentration is approximately 40% of the lumenal concentration, and at 2 mm depth, it reduces to 20%. Ultimately, the concentration drops further and reaches zero at the outer wall boundary.