Immunopathophysiology of food protein-induced enterocolitis syndrome
Immunopathophysiology of food protein-induced enterocolitis syndrome
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DOI：
10.1016/j.jaci.2014.12.1948
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发表时间：
2015-05-01
影响因子：
14.2
通讯作者：
Berin, M. Cecilia
中科院分区：
文献类型：
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作者：
Berin, M. Cecilia
人们越来越认识到非IgE介导的胃肠道食物过敏，称为食物蛋白诱导的小肠结肠炎综合征（FPIES），最近的几篇出版物总结了美国，英国，欧洲和澳大利亚FPIES的临床经验。我们对食物暴露与呕吐、低血压和腹泻等典型症状之间联系的机制的理解远远落后于我们对IgE介导的食物过敏的免疫机制的理解。本概述的目的是总结和批评FPIES免疫学知识的现状，并确定我们的知识中需要解决的主要差距，以在开发FPIES的治疗和预防策略方面取得重大进展。
There is increasing recognition of the non-IgE-mediated gastrointestinal food allergy known as food proteininduced enterocolitis syndrome (FPIES), with several recent publications summarizing the clinical experience with FPIES in the United States, the United Kingdom, Europe, and Australia. Our understanding of the mechanisms linking food exposure to typical symptoms of vomiting, hypotension, and diarrhea has lagged far behind our understanding of the immune mechanisms of IgEmediated food allergy. The goal of this overview is to summarize and critique the current state of knowledge of the immunology of FPIES and to identify major gaps in our knowledge that need to be addressed to make significant gains in developing therapies and prevention strategies for FPIES.