Role of epithelial mesenchymal transition in prostate tumorigenesis.
Role of epithelial mesenchymal transition in prostate tumorigenesis.
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DOI：
10.2174/1381612821666141211120326
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发表时间：
2015
影响因子：
3.1
通讯作者：
Mukhtar H
中科院分区：
文献类型：
--
作者：
Khan MI;Hamid A;Adhami VM;Lall RK;Mukhtar H
在全球范围内，与癌症相关的死亡通常归因于癌细胞或其特征通过一种称为转移的过程扩散到附近或远处的次级器官。在其他因素中，癌细胞的转移性扩散归因于被称为上皮向间充质转化(EMT)的进化保守的发育程序的重新激活。在EMT过程中，完全分化的上皮细胞在形态上经历了一系列戏剧性的变化，细胞与细胞之间的接触丧失，基质重塑为分化较少的侵袭性间充质细胞。许多研究为前列腺癌(PCa)中EMT样状态的存在提供了证据，并提示其可能参与了前列腺癌的进展和转移。与此同时，缺乏确凿证据表明人类PCA样本中存在完整的EMT，这在一定程度上抑制了这一领域的兴趣。然而，正在进行的EMT研究提供了新的视角，并揭示了该领域在为PCA管理量身定做新的治疗方案方面的巨大潜力。本文综述了许多转录因子和其他分子在前列腺癌发生过程中的作用。
Globally, the cancer associated deaths are generally attributed to the spread of cancerous cells or their features to the nearby or distant secondary organs by a process known as metastasis. Among other factors, the metastatic dissemination of cancer cells is attributed to the reactivation of an evolutionary conserved developmental program known as epithelial to mesenchymal transition (EMT). During EMT, fully differentiated epithelial cells undergo a series of dramatic changes in their morphology, along with loss of cell to cell contact and matrix remodeling into less differentiated and invasive mesenchymal cells. Many studies provide evidence for the existence of EMT like states in prostate cancer (PCa) and suggest its possible involvement in PCa progression and metastasis. At the same time, the lack of conclusive evidence regarding the presence of full EMT in human PCa samples has somewhat dampened the interest in the field. However, ongoing EMT research provides new perspectives and unveils the enormous potential of this field in tailoring new therapeutic regimens for PCa management. This review summarizes the role of many transcription factors and other molecules that drive EMT during prostate tumorigenesis.
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DOI：
10.1002/pros.22625
发表时间：
2013-06
期刊：
The Prostate
影响因子：
--
作者：
Chen CL;Mahalingam D;Osmulski P;Jadhav RR;Wang CM;Leach RJ;Chang TC;Weitman SD;Kumar AP;Sun L;Gaczynska ME;Thompson IM;Huang TH
通讯作者：
Huang TH
影响因子：
5.3
作者：
Carver, EA;Jiang, RL;Gridley, T
通讯作者：
Gridley, T
影响因子：
8
作者：
Ezponda, T.;Popovic, R.;Shah, M. Y.;Martinez-Garcia, E.;Zheng, Y.;Min, D-J;Will, C.;Neri, A.;Kelleher, N. L.;Yu, J.;Licht, J. D.
通讯作者：
Licht, J. D.
影响因子：
50.3
作者：
Acevedo, Victor D.;Gangula, Rama D.;Spencer, David M.
通讯作者：
Spencer, David M.
影响因子：
4.8
作者：
Chen, H;Toyooka, S;Hsieh, JT
通讯作者：
Hsieh, JT