Colletotrichum species as emerging opportunistic fungal pathogens:: A report of 3 cases of phaeohyphomycosis and review
Colletotrichum species as emerging opportunistic fungal pathogens:: A report of 3 cases of phaeohyphomycosis and review
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DOI：
10.1067/mjd.2000.113691
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发表时间：
2001-07-01
影响因子：
13.8
通讯作者：
Boyd, AS
中科院分区：
文献类型：
--
作者：
O'Quinn, RP;Hoffmann, JL;Boyd, AS
背景：皮下丝状丝孢菌病的病原学报道很多。炭疽菌(Colletotrichum Spp)是一种常见的植物病原体，已被报道为引起眼部角膜真菌病的原因之一，但仅有一例皮肤疾病(透明丝孢菌病)被归因于该种真菌。目的：我们的目的是描述3例因炭疽菌引起的皮下丝状真菌病，这些病例发生在血液系统恶性肿瘤的化疗患者中。我们介绍了这种感染的临床和组织学特征，报道了其对真菌的敏感性，并讨论了治疗方案。结果：我们描述了第一份报告，其中球菌和胶状芽孢杆菌被认为是皮下感染的病原体。褐丝孢菌病。尽管接受了治疗，一名患者在内脏真菌病发作后死亡。结论：炭疽菌可能会在免疫抑制患者中引起危及生命的褐霉病。及时认识和干预手术和抗真菌治疗可能会降低与这些感染相关的发病率和死亡率。
Background: Numerous etiologic agents of subcutaneous phaeohyphomycosis have been reported. Colletotrichum spp, common plant pathogens, have been reported as a cause of ocular keratomycosis,:but only one previous case of cutaneous disease (hyalohyphomycosis) has been attributed to this genus.Objective: Our purpose was to describe 3 cases of subcutaneous phaeohyphomycosis due to Colletotrichum spp occurring in patients undergoing chemotherapy for hematologic malignancies.Methods: Three cases of Colletotrichum-induced phaeohyphomycosis are reviewed. The clinical and histologic features of this infection are presented, the antifungal susceptibilities are reported, and treatment options are discussed.Results: We describe the first report in which C.coccodes and C gloeosporioides are implicated as etiologic agents of subcutaneous. phaeohyphomycosis. Despite treatment., one patient died after the onset of visceral fungal disease.Conclusion: Colletotrichum spp may cause life-threatening phaeohphomycosis in immunosuppressed patients. Prompt recognition and intervention with surgical and antifungal treatment may result in decreased morbidity and mortality associated with these infections.