The role of the human dorsolateral prefrontal cortex in ocular motor behavior
The role of the human dorsolateral prefrontal cortex in ocular motor behavior
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DOI：
10.1196/annals.1325.023
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Milea, D
中科院分区：
文献类型：
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作者：
Pierrot-Deseilligny, C;Müri, RM;Milea, D
背外侧前额叶皮层（DLPFC）参与准备跳眼运动。病变研究和功能磁共振成像（fMRI）研究表明，人类DLPFC位于Brodmann区46。DLPFC与主要的皮层眼运动区，即额叶的额视野（FEF）和辅助视野（SEF）有直接联系；后顶叶皮质（PPC）有几个（联合、注意和运动）区域，包括顶叶视野（PEF）；扣带视野位于前扣带皮层；在脑干的上丘的直接下游。使用反扫视范式的损伤和fMRI研究表明，DLPFC参与抑制不必要的反身性扫视（由PEF向目标触发），而触发正确的故意反扫视（在与目标相反的方向）可能主要取决于FEE。损伤和经颅磁刺激（TMS）研究表明，DLPFC还控制涉及记忆引导扫视的短期空间工作记忆。中期空间记忆（25秒后）可能由内侧颞叶皮层（MTC）控制。最近，经颅磁刺激（TMS）研究表明，记忆信息从整合顶叶区（PPC）向MTC的传递既可以通过包含DLPFC的间接途径（即串联传递），也可以通过绕过DLPFC的直接途径（即平行传递）。此外，DLPFC还参与了预见性扫视（即在预期目标出现之前进行的扫视）和扫视序列的准备，因此也控制了时间工作记忆的某些方面。最后，最近有报道称DLPFC参与了包括目标选择或为即将到来的扫视做出方向决定的任务。这些不同的功能表明DLPFC在控制眼运动行为的决策过程中起着重要作用。
The dorsolateral prefrontal cortex (DLPFC) is involved in the preparation of saccadic eye movements. Lesion studies and functional magnetic resonance imaging (fMRI) studies suggest that the human DLPFC is located in area 46 of Brodmann. The DLPFC has direct connections with the main cortical ocular motor areas, that is with the frontal eye field (FEF) and the supplementary eye field (SEF) in the frontal lobe; with several (associative, attentional, and motor) areas in the posterior parietal cortex (PPC), including the parietal eye field (PEF); with the cingulate eye field in the anterior cingulate cortex; and directly downstream with the superior colliculus in the brain-stem. Lesion and fMRI studies using the antisaccade paradigm have shown that the DLPFC is involved in the inhibition of unwanted reflexive saccades (triggered toward the target by the PEF), whereas the triggering of correct intentional antisaccades (made in the direction opposite to the target) may depend mainly upon the FEE The DLPFC also controls short-term spatial working memory involved in memory-guided saccades, as shown by lesion and transcranial magnetic stimulation (TMS) studies. By contrast, medium-term spatial memory (after 25 s) may be controlled by the medial temporal cortex (MTC). Recently, TMS studies have suggested that the transmission of memorized information from the integrative parietal areas (PPC) to the MTC is performed via both an indirect pathway comprising the DLPFC (i.e., transmission in series) and a direct pathway bypassing the DLPFC (i.e., transmission in parallel). Furthermore, the DLPFC is involved in the preparation of predictive saccades (i.e., saccades made before the appearance of an expected target) and saccade sequences, and, therefore, also controls some aspects of temporal working memory. Lastly, the involvement of the DLPFC has recently been reported in tasks comprising a target selection or a directional decision to make for the forthcoming saccade. These different functions suggest that the DLPFC plays a major role in the decisional processes governing ocular motor behavior.