Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma
Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma
复制标题
DOI：
10.1159/000080289
复制
发表时间：
2004-01-01
期刊：
影响因子：
3.5
通讯作者：
Imamura, M
中科院分区：
文献类型：
--
作者：
Shimada, Y;Hashimoto, Y;Imamura, M
目的：dysherin是一种与癌症相关的细胞膜糖蛋白，已报道其下调E-cadherin的表达并促进转移。为了评估食管鳞状细胞癌（ESCC）转移过程中异常粘附素的作用，我们检测了食管鳞状细胞癌患者中异常粘附素和E-cadherin的表达。方法：应用免疫组化方法检测117例ESCC患者（pT1、31例；pT2、30例；pT3、39例；pT4、17例）中dysherin和E-cadherin的表达。结果与患者的临床病理资料进行比较。结果：粘附障碍蛋白和e -钙粘蛋白均定位于细胞膜。30例（29.1%）患者出现肿瘤粘附异常阳性，41例（35.0%）患者出现肿瘤E-cadherin阳性。粘附异常阳性和E-cadherin阴性的肿瘤预后明显差于其他肿瘤。当肿瘤异常粘附蛋白阳性患者与e -cadherin阴性患者合并时，该组预后较差（p < 0.0001）。Cox多因素分析显示，粘附不良表达是ESCC的独立预后因素（p = 0.003），而E-cadherin表达不是。结论：联合分析粘附异常蛋白和E-cadherin的表达有助于预测ESCC患者的预后。我们的研究结果表明，这种癌症中粘附异常蛋白的表达可能部分解释了保留E-cadherin表达的患者预后不良的原因。版权所有(C) 2004 S. Karger AG，巴塞尔。
Objective: Dysadherin is a cancer-associated cell membrane glycoprotein that has been reported to downregulate E-cadherin expression and promote metastasis. To evaluate the role of dysadherin in metastasis of esophageal squamous cell carcinoma (ESCC), we examined dysadherin and E-cadherin expression in patients with this cancer. Methods: Dysadherin and E-cadherin expression was evaluated in 117 ESCC patients (pT1, 31; pT2, 30; pT3, 39; pT4, 17) by immunohistochemistry. The findings were compared with the clinicopathological data of the patients. Results: Both dysadherin and E-cadherin were localized to the cell membrane. Thirty patients (29.1%) had tumors positive for dysadherin and 41 patients (35.0%) had tumors positive for E-cadherin. Tumors showing dysadherin positivity and negative E-cadherin expression had a significantly worse prognosis than other tumors. When the patients with dysadherin-positive tumors were combined with E-cadherin-negative patients, this group had a worse prognosis (p < 0.0001). Cox multivariate analysis revealed that dysadherin expression was an independent prognostic factor for ESCC (p = 0.003), but E-cadherin expression was not. Conclusion: Combined analysis of dysadherin and E-cadherin expression may help to predict the prognosis of patients with ESCC. Our results suggested that expression of dysadherin by this cancer may partly explain the poor prognosis of patients with preservation of E-cadherin expression. Copyright (C) 2004 S. Karger AG, Basel.