Synthetic Hydrophilic Materials with Tunable Strength and a Range of Hydrophobic Interactions
Synthetic Hydrophilic Materials with Tunable Strength and a Range of Hydrophobic Interactions
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DOI：
10.1002/adfm.201000170
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发表时间：
2010-07-23
影响因子：
19
通讯作者：
Luzinov, Igor
中科院分区：
文献类型：
--
作者：
Hoy, Olha;Zdyrko, Bogdan;Luzinov, Igor
改变、调节和控制疏水相互作用的能力对于操纵生物对象与水性环境中的合成材料表面之间的相互作用至关重要。为此，合成了接枝聚合物层（多组分混合聚合物刷），其能够在其亲水表面可逆地暴露纳米尺寸的疏水片段，并且能够调节、打开和关闭疏水相互作用。可逆切换响应于环境的变化而发生，并且改变层与水中的疏水性或两亲性探针之间的吸引相互作用的强度和范围。接枝层保持其整体亲水性，而局部疏水力使接枝层能够感测和吸引溶解在水性环境中的蛋白质分子的疏水结构域。材料和疏水探针之间的疏水相互作用的研究，使用原子力显微镜测量和观察到的材料和探针之间的长距离的吸引力和接触粘附的相互作用，这是由环境条件控制。交换层外部也证实通过蛋白质吸附测量。
The ability to vary, adjust, and control hydrophobic interactions is crucial in manipulating interactions between biological objects and the surface of synthetic materials in aqueous environment. To this end a grafted polymer layer (multi-component mixed polymer brush) is synthesized that is capable of reversibly exposing nanometer-sized hydrophobic fragments at its hydrophilic surface and of tuning, turning on, and turning off the hydrophobic interactions. The reversible switching occurs in response to changes in the environment and alters the strength and range of attractive interactions between the layer and hydrophobic or amphiphilic probes in water. The grafted layer retains its overall hydrophilicity, while local hydrophobic forces enable the grafted layer to sense and attract the hydrophobic domains of protein molecules dissolved in the aqueous environment. The hydrophobic interactions between the material and a hydrophobic probe are investigated using atomic force microscopy measurements and a long-range attractive and contact-adhesive interaction between the material and the probe is observed, which is controlled by environmental conditions. Switching of the layer exterior is also confirmed via protein adsorption measurements.