Mechanisms of Tolerance Induction by Dendritic Cells In Vivo.
Mechanisms of Tolerance Induction by Dendritic Cells In Vivo.
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DOI：
10.3389/fimmu.2018.00350
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发表时间：
2018
影响因子：
7.3
通讯作者：
Matsumoto T
中科院分区：
文献类型：
--
作者：
Hasegawa H;Matsumoto T
树突状细胞（DCs）是一个异质性群体，在免疫应答和免疫耐受中发挥关键作用。DCs通过参与胸腺中自身反应性T细胞的阴性选择来促进免疫耐受。此外，为了清除那些逃脱了胸腺清除的自身反应性T细胞，DCs还通过多种机制在外周诱导免疫耐受。这些功能的失调会导致自身免疫性疾病。而且，DCs在维持身体器官（尤其是皮肤和肠道）的内稳态中起着至关重要的作用。在这篇综述中，我们重点关注在我们对体内DCs诱导耐受机制的理解方面的最新进展。
Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune responses and tolerance. DCs promote immune tolerance by participating in the negative selection of autoreactive T cells in the thymus. Furthermore, to eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce immune tolerance in the periphery through various mechanisms. Breakdown of these functions leads to autoimmune diseases. Moreover, DCs play a critical role in maintenance of homeostasis in body organs, especially the skin and intestine. In this review, we focus on recent developments in our understanding of the mechanisms of tolerance induction by DCs in the body.