Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses
Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses
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DOI：
10.1007/s00262-005-0111-9
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发表时间：
2006-10-01
影响因子：
5.8
通讯作者：
Yin, Zhinan
中科院分区：
文献类型：
--
作者：
Gao, Yunfei;Zhang, Dongqing;Yin, Zhinan
活性己糖相关化合物（Active hexose correlated compound，AHCC）是从几种担子菌类蘑菇共培养菌丝体中提取的多糖、氨基酸、脂类和矿物质的混合物。AHCC参与调节免疫功能，并对感染起保护作用。然而，AHCC在肿瘤免疫监视中的潜在作用尚不清楚。在这项研究中，C57 BL/6小鼠口服AHCC或水，然后接种肿瘤细胞。我们发现，与纯水处理的小鼠相比，AHCC处理显著延迟了黑色素瘤细胞系B16 F0或淋巴瘤细胞系EL 4接种后的肿瘤发展。用AHCC治疗增强了Ag特异性活化和CD 4（+）和CD 8（+）T细胞的增殖，增加了肿瘤Ag特异性CD 8（+）T细胞的数量，更重要的是，增加了肿瘤Ag特异性IFN-γ产生的CD 8（+）T细胞的频率。有趣的是，AHCC治疗还显示NK和γ δ T细胞的细胞数量增加，表明AHCC在激活这些先天性淋巴细胞中的作用。总之，我们的研究结果表明，AHCC可以通过调节先天性和适应性免疫应答来增强肿瘤免疫监视。
Active hexose correlated compound (AHCC) is a mixture of polysaccharides, amino acids, lipids and minerals derived from cocultured mycelia of several species of Basidiomycete mushrooms. AHCC has been implicated to modulate immune functions and plays a protective role against infection. However, the potential role of AHCC in tumor immune surveillance is unknown. In this study, C57BL/6 mice were orally administered AHCC or water, followed by tumor cell inoculation. We showed that compared to pure water-treated mice, AHCC treatment significantly delayed tumor development after inoculation of either melanoma cell line B16F0 or lymphoma cell line EL4. Treatment with AHCC enhanced both Ag-specific activation and proliferation of CD4(+) and CD8(+) T cells, increased the number of tumor Ag-specific CD8(+) T cells, and more importantly, increased the frequency of tumor Ag-specific IFN-gamma producing CD8(+) T cells. Interestingly, AHCC treatment also showed increased cell number of NK and gamma delta T cells, indicating the role of AHCC in activating these innate-like lymphocytes. In summary, our results demonstrate that AHCC can enhance tumor immune surveillance through regulating both innate and adaptive immune responses.