Role of basal lamina in Schwann cell glycolipid biosynthesis.
Role of basal lamina in Schwann cell glycolipid biosynthesis.
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基底层在雪旺细胞糖脂生物合成中的作用。
DOI：
10.1007/bf01006818
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发表时间：
1994
影响因子：
4.4
通讯作者：
Yao,JK
中科院分区：
文献类型：
--
作者：
Brunden,KR;Gregory,R;Yoshino,JE;Yao,JK
被剥夺轴突接触的雪旺细胞将其糖脂代谢途径从主要的半乳糖苷（GalCe）合成切换到葡糖脑苷脂（GlcCe）及其同系物的形成。去除轴突的影响对雪旺细胞表型有双重影响;它们失去了组装髓鞘和基底膜的能力。为了确定是否损失的基底膜直接影响糖脂的表达，我们研究了许旺细胞中的脂质生物合成，许旺细胞被允许与背根神经节神经元的轴突相互作用，但被剥夺了组装基底膜的能力。这些雪旺细胞类似于那些来自髓鞘神经的细胞，因为它们合成大量的半乳糖羟化酶。这表明轴突接触，即使在没有基膜的情况下，也足以诱导GalCe代谢途径。
Schwann cells that are deprived of axonal contact switch their glycolipid metabolic pathway from primarily galactocerebroside (GalCe) synthesis to the formation of glucocerebroside (GlcCe) and its homologs. The removal of axonal influence has a dual effect on Schwann cell phenotype; they lose the ability to assemble both myelin and basement membrane. To determine whether a loss of basement membrane directly affects glycolipid expression, we have examined lipid biosynthesis in Schwann cells which were allowed to interact with axons of dorsal root ganglion neurons but which were deprived of the ability to assemble basal lamina. These Schwann cells resemble those from myelinating nerve in that they synthesize a large amount of galactohydroxycerebroside. This suggests that axon contact, even in the absence of basement membrane, is sufficient to induce the GalCe metabolic pathway.