Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
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DOI：
10.1182/blood-2003-05-1545
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发表时间：
2004-01-01
期刊：
影响因子：
20.3
通讯作者：
Chan, WC
中科院分区：
文献类型：
--
作者：
Hans, CP;Weisenburger, DD;Chan, WC
基因芯片显示弥漫性大B细胞淋巴瘤（DLBCL）可分为生发中心B细胞样（GCB）、活化B细胞样（ABC）和3型。从152例DLBCL中制备组织微阵列（TMA）块，其中142例已通过cDNA微阵列成功评估（75例GCB，41例ABC和26例3型）。切片用抗CD 10、bcl-6、MUM 1、FOXP 1、细胞周期蛋白D2和bcl-2的抗体染色。bcl-6表达（P
Diffuse large B-cell lymphoma (DLBCL) can be divided into prognostically important subgroups with germinal center B-cell-like (GCB), activated B-cell-like (ABC), and type 3 gene expression profiles using a cDNA microarray. Tissue microarray (TMA) blocks were created from 152 cases of DLBCL, 142 of which had been successfully evaluated by cDNA microarray (75 GCB, 41 ABC, and 26 type 3). Sections were stained with antibodies to CD10, bcl-6, MUM1, FOXP1, cyclin D2, and bcl-2. Expression of bcl-6 (P